Peeking at Plaque

ROBERT LANGRETH; MATTHEW HERPER

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Peeking at Plaque

机译：偷看斑块

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In drab offices at the cleveland clinic, 11 technicians toil at computer consoles and painstakingly analyze videotape of a peek inside the arteries of ailing heart patients. At stake is the fate of experimental drugs with the potential for billions of dollars in sales. The lab is the brainchild of cardiologist Steven Nissen, who has convinced drug companies that an exotic artery imaging technology called intravascular ultrasound (IVUS) can help them get their products to market much faster. The technique involves threading a miniature ultrasound probe into the coronary artery with a catheter, then taking a three-minute video inside. Technicians use the resulting images to measure the volume of plaque in a segment of an artery; a standard angiogram merely measures obstructions to blood flow. "This has the capacity to cut drug development time in half," says Nissen.

机译：在克利夫兰诊所的单调办公室中，有11名技术人员在计算机控制台上劳作，并仔细分析心脏病患者动脉内窥视的录像带。潜在的实验药物的命运可能会带来数十亿美元的销售额。该实验室是心脏病学家史蒂文·尼森（Steven Nissen）的创意，他说服了制药公司，一种称为血管内超声（IVUS）的奇异动脉成像技术可以帮助他们更快地将其产品推向市场。该技术包括用导管将微型超声探头穿入冠状动脉，然后在内部拍摄三分钟的视频。技术人员使用生成的图像来测量动脉段中的斑块量。标准的血管造影仅能测量血流的阻塞情况。尼森说：“这具有将药物开发时间缩短一半的能力。”

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《Forbes》 |2004年第13期|p.164-165|共2页
作者
ROBERT LANGRETH; MATTHEW HERPER;
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收录信息美国《科学引文索引》(SCI);
原文格式 PDF
正文语种 eng
中图分类世界经济问题;
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7. Figure 1: Distributions of 20 millionp-values each, when Cohen’s standardized effect sized= 0 (bump; A),d= .2 (bump; B), andd= .5 (monotonic excess; C), given data peeking (solid) or no data peeking (dashed). [O] . -1

机译：图1：当COHEN的标准化效果大小= 0（凸块; a），d = .2（bump; b），andd = .5（单调过量; c），给定数据窥视（固体）或没有数据窥视（虚线）。

Peeking at Plaque

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