Color reaction of 3,4-methylenedioxyamphetamines with chromotropic acid: its improvement and application to the screening of seized tablets

Kumi Matsuda; Tomoko Fukuzawa; Yuji Ishii; Hideyuki Yamada

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Color reaction of 3,4-methylenedioxyamphetamines with chromotropic acid: its improvement and application to the screening of seized tablets

机译：3,4-亚甲基二氧基苯丙胺与变色酸的显色反应：其改进及其在缉获片剂筛选中的应用

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摘要

We have previously reported basic data on the specificity of the color reaction of 3,4-methylenedioxymethamphetamine (MDMA) and related drugs with chromotropic acid (CTA) and sulfuric acid. In this communication, we report an extended line of experiments that optimized reaction conditions, and we describe the application of this method to screening for MDMA or 3,4-methylendioxyamphetamine (MDA) in seized tablets. The optimal concentration of CTA and optimal reaction time at room temperature were 1.0 mM and 30 min, respectively. Final concentrations of MDMA of less than 100 μM should be used to avoid nonspecific color development. The CTA-dependent color reaction was also studied using aqueous extracts from seized tablets containing MDMA or MDA. On the basis of our results, we conclude that the present procedure is useful for screening for MDMA and MDA in seized tablets.

机译：我们先前已经报道了有关3,4-亚甲二氧基甲基苯丙胺（MDMA）和相关药物与变色酸（CTA）和硫酸的显色反应特异性的基本数据。在本通讯中，我们报告了优化反应条件的扩展实验范围，并描述了该方法在筛查片剂中筛选MDMA或3,4-甲基二氧苯异丙胺（MDA）的应用。 CTA的最佳浓度和室温下的最佳反应时间分别为1.0 mM和30分钟。 MDMA的最终浓度应小于100μM，以避免产生非特异性的颜色。还使用从缉获的含有MDMA或MDA的片剂中提取的水提取物研究了依赖CTA的显色反应。根据我们的结果，我们得出结论，本程序可用于筛查缉获片剂中的MDMA和MDA。

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来源
《Forensic Toxicology》 |2007年第1期|37-40|共4页
作者
Kumi Matsuda; Tomoko Fukuzawa; Yuji Ishii; Hideyuki Yamada;
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作者单位

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan;

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan;

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan;

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan;

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正文语种 eng
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3; 4-Methylenedioxymethamphetamine (MDMA); 3; 4-Methylenedioxyamphetamine (MDA); Chromotropic acid; Color reaction; Seized tablets;

机译：3;4-亚甲基二氧甲基苯丙胺（MDMA）;3;4-亚甲基二氧甲基苯丙胺（MDA）;致冷酸;显色反应;片剂;

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Color reaction of 3,4-methylenedioxyamphetamines with chromotropic acid: its improvement and application to the screening of seized tablets

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