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Towards personalized medicine: the evolution of imperceptible health-care technologies

机译：迈向个性化医学：潜移默化的医疗技术的发展

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摘要

Purpose - When wearable and implantable devices first arose in the 1970s, they were rigid and clashed dramatically with our soft, pliable skin and organs. The past two decades have witnessed a major upheaval in these devices. Traditional electronics are six orders of magnitude stiffer than soft tissue. As a result, when rigid electronics are integrated with the human body, severe challenges in both mechanical and geometrical form mismatch occur. This mismatch creates an uneven contact at the interface of soft-tissue, leading to noisy and unreliable data gathering of the body's vital signs. This paper aims to predict the role that discreet, seamless medical devices will play in personalized health care by discussing novel solutions for alleviating this interface mismatch and exploring the challenges in developing and commercializing such devices. Design methodology/approach - Since the form factors of biology cannot be changed to match those of rigid devices, conformable devices that mimic the shape and mechanical properties of soft body tissue must be designed and fabricated. These conformable devices play the role of imperceptible medical interfaces. Such interfaces can help scientists and medical practitioners to gain further insights into the body by providing an accurate and reliable instrument that can conform closely to the target areas of interest for continuous, long-term monitoring of the human body, while improving user experience. Findings - The authors have highlighted current attempts of mechanically adaptive devices for health care, and the authors forecast key aspects for the future of these conformable biomedical devices and the ways in which these devices will revolutionize how health care is administered or obtained. Originality/value - The authors conclude this paper with the perspective on the challenges of implementing this technology for practical use, including device packaging, environmental life cycle, data privacy, industry partnership and collaboration.
机译：目的-当可穿戴和可植入设备在1970年代首次出现时，它们是刚性的，与我们柔软，柔软的皮肤和器官剧烈碰撞。在过去的二十年中，这些设备发生了重大变化。传统电子产品比软组织要硬六个数量级。结果，当刚性电子设备与人体集成在一起时，在机械和几何形式不匹配方面都会出现严峻的挑战。这种失配会在软组织的界面处产生不均匀的接触，从而导致嘈杂且不可靠的身体生命体征数据收集。本文旨在通过讨论减轻接口不匹配的新颖解决方案，并探索开发和商业化此类设备的挑战，来预测谨慎，无缝的医疗设备在个性化医疗保健中将扮演的角色。设计方法/方法-由于无法更改生物学的形状因子以匹配刚性设备的形状因子，因此必须设计和制造模仿软组织的形状和机械特性的顺应性设备。这些合格的设备起着难以察觉的医学接口的作用。这样的界面可以通过提供一种精确可靠的仪器来帮助科学家和医学从业者获得对人体的进一步了解，该仪器可以紧密贴近目标目标区域，以连续，长期地监视人体，同时改善用户体验。调查结果-作者强调了目前用于医疗保健的机械自适应设备的尝试，并且作者预测了这些顺应性生物医学设备的未来的关键方面以及这些设备将彻底改变医疗管理或获得方式的方式。独创性/价值-作者在总结本文时的观点是针对在实际应用中实施该技术所面临的挑战，包括设备包装，环境生命周期，数据隐私，行业合作和协作。

著录项

  • 来源
    《Foresight》 |2018年第6期|589-601|共13页
  • 作者

    Farita Tasnim; Atieh Sadraei; Bianca Datta; Mina Khan; Kyung Yun Choi; Atharva Sahasrabudhe; Tomas Alfonso Vega Galvez; Irmandy Wicaksono; Oscar Rosello; Carlos Nunez-Lopez; Canan Dagdeviren;

  • 作者单位

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA and Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

    Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Research; Innovation; Personal health; Nanotechnology; Biotechnology; Forecasting;

    机译：研究;革新;个人健康;纳米技术;生物技术;预测;

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