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The evolution of personalized cancer genetic counseling in the era of personalized medicine

机译:个性化医学时代的个性化癌症遗传咨询的发展

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摘要

Practice changes in cancer genetic counseling have occurred to meet the demand for cancer genetic services. As cancer genetics continues to impact not only prevention strategies but also treatment decisions, current cancer genetic counseling models will need to be tailored to accommodate emerging clinical indications. These clinical indications include: surgical prophylactic bilateral mastectomy candidates, PARP-inhibitor candidates, patients with abnormal tumor screening results for Lynch syndrome, and post-test counseling patients (after genetic testing is ordered by another healthcare provider). A more personalized, multidisciplinary approach to selecting the best framework, for a given clinical indication, may become increasingly necessary in this era of personalized medicine.
机译:癌症遗传咨询的实践发生了变化,以满足对癌症遗传服务的需求。由于癌症遗传学不仅继续影响预防策略,而且影响治疗决策,因此,当前的癌症遗传咨询模型将需要量身定制,以适应新出现的临床适应症。这些临床适应症包括:手术预防性双侧乳房切除术候选者,PARP抑制剂候选者,Lynch综合征肿瘤筛查结果异常的患者以及测试后咨询患者(在另一家医疗服务提供者下令进行基因测试之后)。在这种个性化医学时代,针对给定的临床适应症选择最佳框架的更加个性化,多学科的方法可能变得越来越必要。

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