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Investigation of eukaryotic protein trafficking with bacterial cytolethal distending toxin

机译:细菌细胞致死性膨胀毒素对真核蛋白运输的研究

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摘要

Protein trafficking is the process of moving proteins from one cellular compartment to another by various sorting and transport mechanisms. One especially important process is protein dislocation, the transport of proteins from the endoplasmic reticu-lum (ER) lumen into the cytosol across the ER membrane. In particular, proteins destined for secretion are targeted to the ER during synthesis, where they undergo modifications such as glycosylation, attachment of lipid residues or disulfide bond formation. Incorrectly folded or post-translationally modified proteins that fail to pass ER-internal quality control are subsequently dislocated across the ER membrane into the cytosol to be degraded by the proteasome.
机译:蛋白质运输是通过各种分类和运输机制将蛋白质从一个细胞区室转移到另一个细胞室的过程。一个特别重要的过程是蛋白质脱位,即蛋白质从内质网(ER)内腔穿过ER膜进入细胞质。特别地,将要分泌的蛋白质在合成过程中靶向到ER,在此处进行修饰,例如糖基化,脂质残基附着或二硫键形成。不能通过ER内部质量控制的折叠不正确或翻译后修饰的蛋白随后穿过ER膜进入胞质溶胶中,并被蛋白酶体降解。

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  • 来源
    《Futura》 |2009年第2期|121-123|共3页
  • 作者

    Irene Wuethrich;

  • 作者单位

    Whitehend Institute for Biomedical Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA;

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  • 正文语种 eng
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