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首页> 外文期刊>Deutsche Zeitschrift fur Sportmedisin >Medikamentöse Therapie der Hypercholesterinämie
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Medikamentöse Therapie der Hypercholesterinämie

机译:高胆固醇血症的药物治疗

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Lipids play an important role for both development and therapy of atherosclerosis. Li-pid lowering drugs do not only reduce accumulation of lipids in the arterial wall but also stabilize plaques and affect endothelial function favorably. To treat hypercholesterinemia statins are compounds of primary choice. If combined hyperlipidemia is present fi-brates may also be used. The aim of therapy depends on further risk factors and on the presence of coronary artery disease. There is no doubt that in patients with coronary heart disease statins reduce recurrence of myocar-dial infarction, clinical events, frequency of operative interventions and total mortality. In patients suffering from myocardial infarction without hypercholesterinemia and in hypercholesterinemic patients without myo-cardial infarction the application of lipid lowering drugs is also useful.
机译:脂质对于动脉粥样硬化的发展和治疗都起着重要作用。降低Li-pid的药物不仅可以减少脂质在动脉壁中的积累,而且可以稳定斑块并有利地影响内皮功能。为了治疗高胆固醇血症,他汀类药物是首选化合物。如果存在合并的高血脂症,也可以使用贝特类药物。治疗的目标取决于其他危险因素和冠状动脉疾病的存在。毫无疑问,冠心病患者他汀类药物可减少心肌梗塞的复发,临床事件,手术干预的频率和总死亡率。在没有高胆固醇血症的心肌梗塞患者和没有心肌梗塞的高胆固醇血症患者中,降脂药物的应用也是有用的。

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