首页> 中国专利> 金纳米团簇于治疗高胆固醇血症或与高胆固醇血症相关的疾病的用途

金纳米团簇于治疗高胆固醇血症或与高胆固醇血症相关的疾病的用途

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摘要

本发明是关于涂覆了二氢硫辛酸(DHLA)的金纳米团簇在制备用于治疗个体的高胆固醇血症或与高胆固醇血症相关的疾病的药物中的用途，所述金纳米团簇的粒径约为1到10纳米。

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公开/公告号CN113795277A

专利类型发明专利
公开/公告日2021-12-14

原文格式PDF
申请/专利权人叶宏一;李亦男;王学孝;红婴生物科技股份有限公司;
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申请/专利号CN201980095582.7
发明设计人叶宏一;李亦男;张恒雄;李冠瑢;赖韦中;王学孝;
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申请日2019-05-07
分类号A61K47/00(20060101);A61P3/06(20060101);
代理机构11017 北京华夏正合知识产权代理事务所(普通合伙);
代理人韩登营;荣文英
地址中国台湾台北市
入库时间 2023-06-19 13:41:59

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1. 金纳米团簇于治疗高胆固醇血症或与高胆固醇血症相关的疾病的用途 [P] . 中国专利： CN113795277A . 2021-12-14
2. 治疗肥胖、胰岛素相关的疾病和高胆固醇血症的方法和组合物 [P] . 中国专利： CN1988912B . 2013.01.30
3. compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, methods of treatment and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, and to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, type 2 diabetes arteriosclerosis, conditions associated with the need to improve hdl function, and pharmaceutical composition [P] . BRPI0412472A . 2006-09-19

机译：化合物，化合物的制备方法，药物制剂，化合物的用途，治疗和/或预防与胰岛素抵抗相关或不相关的脂质疾病（血脂异常）和动脉粥样硬化的方法，心血管疾病，高胆固醇血症的治疗和/或预防方法与需要改善胆固醇逆向转运，减少肠内胆固醇吸收，增加HDL胆固醇水平，降低胆固醇水平相关的疾病。 ldl，炎性疾病，阿尔茨海默氏病，2型糖尿病动脉硬化，与需要改善hdl功能相关的疾病以及药物成分
4. compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, and methods of treating and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, atherosclerosis, type 2 diabetes, and conditions associated with the need to improve hdl function, and pharmaceutical composition [P] . BRPI0412479A . 2006-09-19

机译：化合物，制备化合物的方法，药物制剂，化合物的用途，治疗和/或预防与胰岛素抵抗相关或不相关的脂质疾病（血脂异常）和动脉粥样硬化的方法，以及治疗和/或预防心血管疾病的方法，高胆固醇血症，与需要改善胆固醇逆向转运，减少肠内胆固醇吸收，增加HDL胆固醇水平，降低胆固醇水平相关的疾病。 IDL，炎性疾病，阿尔茨海默氏病，动脉粥样硬化，2型糖尿病以及与需要改善HDL功能相关的疾病以及药物成分
5. pcsk9 inhibitors, inhibited pcsk9, pharmaceutical composition, methods to modulate pcsk9 activity, to inhibit binding of pcsk9 to ldlr, to increase ldlr availability, to reduce ldl-c level, to reduce serum ldl level -c, for the treatment of a cholesterol-related disorder, methods for treating a disorder associated with an abnormal level of ldl-c, a condition associated with a high level of ldl-c, dyslipidemia, hypercholesterolemia, uses of a pcsk9 inhibitor and method for identifying a candidate compound as a pcsk9 inhibitor that binds an epitope of seq id # 1 [P] . BR112018076242A2 . 2019-03-26

机译： pcsk9抑制剂，抑制的pcsk9，药物组合物，调节pcsk9活性，抑制pcsk9与ldlr结合，增加ldlr利用率，降低ldl-c水平，降低血清ldl水平-c的方法，用于治疗胆固醇-相关疾病，与ldl-c异常水平相关的疾病，与ldl-c高水平相关的疾病，血脂异常，高胆固醇血症的治疗方法，pcsk9抑制剂的用途以及鉴定候选化合物为pcsk9抑制剂的方法结合seq id＃1的表位