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Conceptions within misconceptions: Pluralisms in an Ebola vaccine trial in West Africa

机译：误解中的观念：西非埃博拉疫苗试验中的多元化

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摘要

Ensuring that biomedical information about research procedures is adequately understood by participants and their communities is key for conducting ethical research. This article explores participants' understanding of trial procedures for an experimental vaccine against Ebola virus disease (EVD) in a West African context. We found that some trial participants believed there was a chance of contracting Ebola and other sicknesses from the vaccine, and others believed both the vaccine and the placebo control would be able to prevent other illnesses than EVD. While these beliefs might be understood as misconceptions about the vaccine trial, this paper shows that such a conclusion is problematic because it excludes local explanatory health models and logics of causality. The paper invites bioethicists to work with anthropologists to take seriously different models of health knowledge in global health research. Investigating and addressing such differences could be the key to understanding human subjects' motives for participation, and to creating space for studies of empirical ethics.
机译：确保参与者及其所在社区充分了解有关研究程序的生物医学信息是进行伦理研究的关键。本文探讨了参与者对在西非背景下针对埃博拉病毒病（EVD）的实验疫苗的试验程序的理解。我们发现，一些试验参与者认为该疫苗可能会感染埃博拉和其他疾病，而另一些人则认为该疫苗和安慰剂对照都能够预防除EVD之外的其他疾病。虽然这些信念可能被理解为对疫苗试验的误解，但本文表明，这样的结论是有问题的，因为它排除了当地的解释性健康模型和因果逻辑。该论文邀请生物伦理学家与人类学家合作，在全球健康研究中采用不同的健康知识模型。调查和解决此类差异可能是理解人类受试者参与动机以及为实证伦理学研究创造空间的关键。

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