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首页> 外文期刊>Harmful Algae >Microcystins and two new micropeptin cyanopeptides produced by unprecedented Microcystis aeruginosa blooms in North Carolina's Cape Fear River
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Microcystins and two new micropeptin cyanopeptides produced by unprecedented Microcystis aeruginosa blooms in North Carolina's Cape Fear River

机译：由空前的铜绿微囊藻产生的微囊藻毒素和两种新的微肽蓝藻多肽在北卡罗来纳州的Cape Fear River盛开

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The Cape Fear River is the largest river system in North Carolina. It is heavily used as a source of drinking water for humans and livestock as well as a source of irrigation water for crops, and production water for industry. It also serves as a major fishery for both commercial and recreational use. In recent years, possibly related to increased eutrophication of the river, massive blooms of cyanobacteria, identified as Microcystis aeruginosa have been observed. Bloom samples collected in 2009 and 2012 were chemically analyzed to determine if they contained cyanobacterial toxins known as microcystins. Both blooms were found to produce microcystins in high yields. Microcystins are potent hepatotoxins that can be bio-accumulated in the food chain. Recent biological studies have also shown a host of other potentially harmful effects of low level microcystin exposure. Detailed chemical analysis of these blooms led us to discover that these blooms produce an additional family of cyanobacterial peptides know as the micropeptins, including two new members named micropeptins 1106 and 1120. The biological activities of these new molecules have not yet been determined, although protease activity has been well documented for this peptide group. These data indicate a need for thorough monitoring of toxin levels especially during bloom events in addition to additional biological testing of other cyanopeptides present in blooms.
机译：恐惧角河是北卡罗来纳州最大的河流系统。它被广泛用作人类和牲畜的饮用水水源，也被用作农作物的灌溉水和工业用水。它也是商业和休闲用途的主要渔业。近年来，可能与河水富营养化有关，已观察到蓝细菌大量繁殖，这些细菌被鉴定为铜绿微囊藻。对2009年和2012年采集的Bloom样品进行化学分析，以确定它们是否含有被称为微囊藻毒素的蓝细菌毒素。发现两种花都以高产量产生微囊藻毒素。微囊藻毒素是有效的肝毒素，可以在食物链中进行生物蓄积。最近的生物学研究还表明，低水平的微囊藻毒素暴露还会带来许多其他潜在的有害影响。对这些水华的详细化学分析使我们发现，这些水华产生了另一类称为微肽的蓝细菌肽，包括两个名为微肽1106和1120的新成员。这些新分子的生物学活性尚未确定，尽管蛋白酶该肽组的活性已被充分证明。这些数据表明，除了对花朵中存在的其他氰基肽进行其他生物学测试以外，还需要对毒素水平进行全面监控，尤其是在花朵事件期间。

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