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首页> 外文期刊>Harmful Algae >7-Deoxy-desulfo-cylindrospermopsin and 7-deoxy-desulfo-12-acetylcylindrospermopsin: Two new cylindrospermopsin analogs isolated from a Thai strain of Cylindrospermopsis raciborskii
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7-Deoxy-desulfo-cylindrospermopsin and 7-deoxy-desulfo-12-acetylcylindrospermopsin: Two new cylindrospermopsin analogs isolated from a Thai strain of Cylindrospermopsis raciborskii

机译：7-脱氧-脱硫-cylindrospermopsin和7-脱氧-脱硫-cylindrospermopsin：从泰国的Cylindrospermopsis raciborskii菌株中分离出的两个新的cylindrospermopsin类似物。

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摘要

As environmental changes such as eutrophication lead to increased size and frequency of cyanobacterial blooms, research into the toxins produced by these blooms becomes increasingly important. One of the common toxins produced by cyanobacterial blooms is cylindrospermopsin (1), a potent inhibitor of protein synthesis. To date, only two additional analogs of cylindrospermopsin have been isolated, namely 7-epicylindrospermopsin (2) and 7-deoxy-cylindrospermopsin (3). This report details the isolation and structure determination of an additional two new analogs, 7-deoxy-desulfo-cylindros-permopsin (4) and 7-deoxy-desulfo-12-acetylcylindrospermopsin (5). These are the first new analogs of cylindrospermopsin to be reported in over a decade. Based on their structural features, it is likely that these new analogs also possess the harmful biological activities displayed by the rest of the cylindrospermopsin family.
机译：随着诸如富营养化之类的环境变化导致蓝细菌水华的大小和频率增加，对由这些水华产生的毒素的研究变得越来越重要。蓝藻绽放产生的常见毒素之一是cylindrospermopsin（1），一种有效的蛋白质合成抑制剂。迄今为止，仅分离出了两种环孢菌胃蛋白酶的类似物，即7-表皮吲哚肌蛋白酶（2）和7-脱氧环孢菌蛋白酶（3）。该报告详细介绍了另外两种新的类似物7-脱氧-脱硫-cylindros-permopsin（4）和7-脱氧-脱硫-12-乙酰基cylindros-permopsin（5）的分离和结构测定。这些是十余年来首次报道的环精皮蛋白新类似物。基于它们的结构特征，这些新的类似物也可能具有其余的cylindrospermopsin家族所展示的有害生物活性。

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