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首页> 外文期刊>Heat Transfer Engineering >Fouling in a Micro Heat Exchanger During Continuous Crystallization of Solid Lipid Nanoparticles
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Fouling in a Micro Heat Exchanger During Continuous Crystallization of Solid Lipid Nanoparticles

机译：固体脂质纳米颗粒连续结晶过程中在微型换热器中结垢

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摘要

During the continuous crystallization of various solid lipid nanoparticle (LNP) formulations, certain formulations lead to fouling and blocking of small passages in the applied micro heat exchanger. In order to investigate the fouling behavior of different LNP formulations in detail, integral fouling evaluations by pressure drop measurements were performed. Results show more fluctuations compared to particle fouling experiments in macro devices. These variations result from detached agglomerates from compounds formed in micro devices in the inlet header regions, breaking off randomly due to shear stress. This results in downstream microchannel blockage, in the transfer tubings or in subsequent unit operations. During corresponding cleaning experiments different observations compared to macro dimensions were made: Based on significant lower ratios of characteristic dimension of the microchannel to particle or agglomerate diameter, agglomerates remain in the microchannels, preventing smaller particles from being washed off (i.e., capturing effect). Furthermore, low Reynolds numbers, high surface-to-volume ratios, and small characteristic dimensions may result in a total blockage of microchannels.
机译：在各种固体脂质纳米颗粒（LNP）配方的连续结晶过程中，某些配方会导致结垢并阻塞所应用的微型热交换器中的小通道。为了详细研究不同LNP配方的结垢行为，通过压降测量进行了整体结垢评估。结果表明，与大型设备中的颗粒污染实验相比，波动更大。这些变化是由于在入口集管区域中的微型设备中形成的化合物从附聚物上脱离而引起的，由于剪切应力而随机断开。这导致下游微通道堵塞，输送管或后续单元操作中的堵塞。在相应的清洁实验中，与宏观尺寸相比有不同的观察结果：基于微通道特征尺寸与颗粒或团聚体直径的显着较低的比率，团聚体保留在微通道中，防止较小的颗粒被冲洗掉（即捕获效果）。此外，雷诺数低，表面积/体积比高和特征尺寸小可能会导致微通道的完全堵塞。

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  • 来源
    《Heat Transfer Engineering》 |2015年第8期|731-740|共10页
  • 作者

    MARTIN SCHOENITZ; JAN HENRIK FINKE; SEBASTIAN MELZIG; ANNIKA HOHLEN; NILS WARMELING; CHRISTEL MUELLER-GOYMANN; WOLFGANG AUGUSTIN; STEPHAN SCHOLL;

  • 作者单位

    Technische Universitaet Braunschweig, Institute for Chemical and Thermal Process Engineering, Braunschweig, Germany;

    Technische Universitaet Braunschweig, Institute for Pharmaceutical Technology, Braunschweig, Germany;

    Technische Universitaet Braunschweig, Institute for Chemical and Thermal Process Engineering, Braunschweig, Germany;

    Technische Universitaet Braunschweig, Institute for Chemical and Thermal Process Engineering, Braunschweig, Germany;

    Technische Universitaet Braunschweig, Institute for Chemical and Thermal Process Engineering, Braunschweig, Germany;

    Technische Universitaet Braunschweig, Institute for Pharmaceutical Technology, Braunschweig, Germany;

    Technische Universitaet Braunschweig, Institute for Chemical and Thermal Process Engineering, Langer Kamp 7, 38106, Braunschweig, Germany;

    Technische Universitaet Braunschweig, Institute for Chemical and Thermal Process Engineering, Braunschweig, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
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