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首页> 外文期刊>Computational Biology and Bioinformatics, IEEE/ACM Transactions on >Synthesis of Genetic Clock with Combinational Biologic Circuits
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Synthesis of Genetic Clock with Combinational Biologic Circuits

机译：组合生物电路遗传时钟的合成

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The potential of genetic clock lies in its role to triggering logic reaction for sequential biological circuits. In general, biochemical reaction of the biological system is extremely slow. However, a square wave generator used as a genetic clock the transient response should be fast enough to catch the reaction change between two logic levels. Therefore, the requirement for instantaneous changes in logic status is not likely to exist in biological systems. This paper presents a method of synthesizing a genetic clock generator based on the combination of a toggle switch with two biological logic gates. A dual repressor is used to connect the two fundamental biologic circuits. Analysis of the characteristic responses of this genetic clock with its relation to the key parameters is provided.
机译：基因时钟的潜力在于其触发顺序生物回路的逻辑反应的作用。通常，生物系统的生化反应非常缓慢。但是，将方波发生器用作遗传时钟，其瞬态响应应足够快，以捕获两个逻辑电平之间的反应变化。因此，在生物系统中不太可能需要瞬时改变逻辑状态。本文提出了一种基于触发器开关与两个生物逻辑门的组合来合成遗传时钟发生器的方法。双重阻遏物用于连接两个基本生物学电路。提供了对该遗传钟的特征响应及其与关键参数的关系的分析。

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