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Miniature In Vivo Chitosan Diaphragm-Based Fiber-Optic Ultrasound Sensor

机译:基于微型壳聚糖膜片的光纤超声传感器

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摘要

A fiber-optic Fabry–Perot interferometric chitosan membrane hydrophone for in vivo ultrasound measurements is proposed. The hydrophone is based on a thin chitosan film acting as a low-finesse Fabry–Perot cavity that is formed at the tip of hollow core fiber. Chitosan membrane provides maximum acoustic impedance matching for in vivo ultrasound measurement and optimizes the matched-loading condition due to its permeable property. The transduction mechanism is based on acoustically induced mechanical deformation of the chitosan sensing interferometer, which exhibits a voltage sensitivity of 0.5 mV/MPa or −306 dB re 1 V/μPa without the use of filtering and external preamplifiers. The sensor shows frequency response from 1 to 20 MHz in the presence of acoustic amplitude level up to 4 MPa with a minimum detectable pressure of 40 kPa. The wideband sensitive response, biocompatibility, and easy functionalization of chitosan membrane suggest the possibility for accurate and reliable measurements of exposure levels encountered in in vivo ultrasound measurements and may find applications as an alternative to piezoelectric hydrophone for ultrasound characterizations.
机译:提出了一种用于体内超声测量的光纤法布里-珀罗干涉壳聚糖膜水听器。水听器基于薄壳聚糖薄膜,该薄膜起着中空纤维尖端形成的低精细法布里-珀罗腔的作用。壳聚糖膜为体内超声测量提供最大的声阻抗匹配,并由于其可渗透性而优化了匹配的负载条件。转导机制基于壳聚糖传感干涉仪的声学感应机械变形,该机械变形在不使用滤波和外部前置放大器的情况下表现出0.5 mV / MPa或-306 dB re 1 V /μPa的电压灵敏度。该传感器在存在高达4 MPa的声振幅级且最小可检测压力为40 kPa的情况下显示1至20 MHz的频率响应。壳聚糖膜的宽带敏感响应,生物相容性和容易的功能化表明可能对体内超声测量中遇到的暴露水平进行准确而可靠的测量,并且可能找到替代压电水听器进行超声表征的应用。

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