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首页> 外文期刊>Magnetics, IEEE Transactions on >Toward Detection of Transient Changes in Magnetic-Resonance Signal Intensity Arising From Neuronal Electrical Activities
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Toward Detection of Transient Changes in Magnetic-Resonance Signal Intensity Arising From Neuronal Electrical Activities

机译：旨在检测由神经元电活动引起的磁共振信号强度的瞬态变化

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摘要

Detection of weak magnetic fields arising from neuronal electrical activities using magnetic-resonance imaging (MRI) is a potentially effective method for functional imaging of the brain. The purpose of this study is to theoretically and experimentally assess the influence of neuronal magnetic fields on magnetic-resonance signals. The neuronal magnetic field was modeled by using a current dipole formula, and the resulting magnetic-resonance signals were calculated for a voxel located close to the dipole. A current dipole strength of 12 nA$cdot$m resulted in the maximum signal drop of 0.6%. In the experiments, magnetic-resonance images of the rat brain were obtained by using a 4.7-T MRI system. A pair of electrodes was attached to the left sciatic nerve for electric stimulation. Images were obtained at ten time points of 0, 30, 60, $ldots$, and 270 ms after the electric stimulation. In the right somatosensory cortex, a transient decrease in the signal intensity was found at 0–30 ms after the stimulation, which was attributed to the effects of neuronal magnetic fields. A neuronal activation map was generated by a comparison of signal intensities between the images obtained at 30–60 ms and 60–90 ms. The right somatosensory cortex exhibited a statistically significant difference in these two groups of images.
机译：使用磁共振成像（MRI）检测由神经元电活动引起的弱磁场是对大脑进行功能成像的潜在有效方法。这项研究的目的是从理论和实验上评估神经元磁场对磁共振信号的影响。通过使用当前的偶极子公式对神经元磁场进行建模，并对位于偶极子附近的体素计算得到的磁共振信号。电流偶极强度为12 nA $ cdot $ m导致最大信号降为0.6％。在实验中，通过使用4.7-T MRI系统获得了大鼠大脑的磁共振图像。一对电极连接到左坐骨神经以进行电刺激。在电刺激后的十个时间点分别为0、30、60，l和270 ms获得图像。在右侧的体感皮层中，在刺激后0–30 ms处发现信号强度的瞬时下降，这归因于神经元磁场的作用。通过比较在30–60 ms和60–90 ms处获得的图像之间的信号强度来生成神经元激活图。在这两组图像中，右体感皮层显示出统计学上的显着差异。

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