A study on statistically reliable and computationally efficient algorithms for generating local cerebral blood flow parametric images with positron emission tomography

Feng D.; Wang Z.

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A study on statistically reliable and computationally efficient algorithms for generating local cerebral blood flow parametric images with positron emission tomography

机译：利用正电子发射断层扫描生成局部脑血流参数图像的统计可靠且计算效率高的算法的研究

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With the advent of positron emission tomography (PET), a variety of techniques have been developed to measure local cerebral blood flow (LCBF) noninvasively in humans. A potential class of techniques, which includes linear least squares (LS), linear weighted least squares (WLS), linear generalized least squares (GLS), and linear generalized weighted least squares (GWLS), is proposed. The statistical characteristics of these methods are examined by computer simulation. The authors present a comparison of these four methods with two other rapid estimation techniques developed by Huang et al. (1982) and Alpert (1984), and two classical methods, the unweighted and weighted nonlinear least squares regression. The results show that these methods can take full advantage of the contribution from the fine temporal sampling data of modern tomographs, and thus provide statistically reliable estimates that are comparable to those obtained from nonlinear LS regression. These methods also have high computational efficiency, and the parameters can be estimated directly from operational equations in one single step. Therefore, they can potentially be used in image-wide estimation of local cerebral blood flow and distribution volume with PET.

机译：随着正电子发射断层扫描（PET）的出现，已经开发了多种技术来无创地测量人体的局部脑血流（LCBF）。提出了一种潜在的技术类别，包括线性最小二乘（LS），线性加权最小二乘（WLS），线性广义最小二乘（GLS）和线性广义加权最小二乘（GWLS）。通过计算机仿真检查了这些方法的统计特性。作者将这四种方法与Huang等人开发的另外两种快速估算技术进行了比较。（1982）和Alpert（1984），以及两种经典方法，即非加权和加权非线性最小二乘回归。结果表明，这些方法可以充分利用现代断层扫描仪精细时间采样数据的贡献，从而提供与非线性LS回归可比的统计可靠估计。这些方法还具有很高的计算效率，并且可以在一个步骤中直接从运算方程式估算参数。因此，它们可以潜在地用于PET的全图像范围的局部脑血流和分布体积估计。

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《IEEE Transactions on Medical Imaging》 |1993年第2期|P.182-188|共7页
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Feng D.; Wang Z.;
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中图分类无线电电子学、电信技术;
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1. Formation of statistically reliable parametric image in positron emission tomography - effect of incorporating hierarchal clustering algorithm [J] . Yasuhiro Noshi, Yuichi Kimura, Akihiko Uchiyama 電子情報通信学会技術研究報告. 医用画像. Medical Imaging . 2001,第239期

机译：正电子发射断层扫描中统计可靠的参数图像的形成-结合层次聚类算法的效果
2. Formation of statistically reliable parametric image in positron emission tomography - effect of incorporating hierarchal clustering algorithm [J] . Yasuhiro Noshi, Yuichi Kimura, Akihiko Uchiyama 電子情報通信学会技術研究報告. 医用画像. Medical Imaging . 2001,第239期

机译：在正电子发射断层扫描中形成统计上可靠的参数图像 - 掺入分层聚类算法的效果
3. Evaluation of Basis Function and Linear Least Squares Methods for Generating Parametric Blood Flow Images Using 15O-Water and Positron Emission Tomography [J] . Ronald Boellaard PhD, Paul Knaapen MD, Abraham Rijbroek MD, Molecular Imaging and Biology . 2005,第4期

机译：基于15 O-水和正电子发射断层扫描技术生成参数血流图像的基函数和线性最小二乘法方法的评估
4. Development of Fully Automatic Technique to Generate Parametric Images of Myocardial Blood Flow with 15{sup left}O-Water and Positron Emission Tomography using Basis Function Method [C] . Hiroshi Watabe, Kazuhiro Koshino, Noboru Teramoto, IEEE Nuclear Science Symposium . 2005

机译：使用基函数方法产生15 {Sup左} O-Water和正电子发射断层扫描产生心肌血流参数图像的全自动技术
5. Cerebral Blood Flow Measurements Using Carotid Artery Image-Derived Input Functions in Positron Emission Tomography. [D] . Fung, Edward Komin. 2013

机译：在正电子发射断层扫描中使用颈动脉图像衍生的输入函数进行脑血流量测量。
6. Spatial coefficient of variation in pseudo-continuous arterial spin labeling cerebral blood flow images as a hemodynamic measure for cerebrovascular steno-occlusive disease: A comparative 15O positron emission tomography study [O] . Masanobu Ibaraki, Kazuhiro Nakamura, Hideto Toyoshima, 2019

机译：伪连续动脉自旋标记脑血流图像的空间变异系数作为脑血管狭窄闭塞性疾病的血流动力学指标：比较的15O正电子发射断层扫描研究
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机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。
8. Local Cerebral Blood Flow (1CBF) and Oxygen Consumption (1CMRO sub 2 ) in Evolving Irreversible Ischemic Infarction: A Study with Positron Tomography and Oxygen-15 [R] . Baron, J. C., Rougemont, D., Lebrun-Grandie, P., 1982

机译：局部脑血流量（1CBF）和耗氧量（1CmRO sub 2）在进展性不可逆性缺血性脑梗死中的应用：正电子断层扫描和氧气研究15

A study on statistically reliable and computationally efficient algorithms for generating local cerebral blood flow parametric images with positron emission tomography

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