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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >3-D Microvascular Imaging Using High Frame Rate Ultrasound and ASAP Without Contrast Agents: Development and Initial In Vivo Evaluation on Nontumor and Tumor Models
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3-D Microvascular Imaging Using High Frame Rate Ultrasound and ASAP Without Contrast Agents: Development and Initial In Vivo Evaluation on Nontumor and Tumor Models

机译：使用高帧频超声和ASAP而不使用造影剂的3D微血管成像：非肿瘤和肿瘤模型的开发和初始体内评估

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摘要

Three-dimensional imaging is valuable to noninvasively assess angiogenesis given the complex 3-D architecture of vascular networks. The emergence of high frame rate (HFR) ultrasound, which can produce thousands of images per second, has inspired novel signal processing techniques and their applications in structural and functional imaging of blood vessels. Although highly sensitive vascular mapping has been demonstrated using ultrafast Doppler, the detectability of microvasculature from the background noise may be hindered by the low signal-to-noise ratio (SNR) particularly in the deeper region and without the use of contrast agents. We have recently demonstrated a coherence-based technique, acoustic subaperture imaging (ASAP), for super-contrast vascular imaging and illustrated the contrast improvement using HFR contrast-enhanced ultrasound. In this work, we provide a feasibility study for microvascular imaging using ASAP without contrast agents, and extend its capability from 2-D to volumetric vascular mapping. Using an ultrasound research system and a preclinical probe, we demonstrated the improved visibility of microvascular mapping using ASAP in comparison to ultrafast power Doppler (PD) on a mouse kidney, liver, and tumor without contrast agent injection. The SNR of ASAP images improves in average by 10 dB when compared to PD. In addition, directional velocity mappings were also demonstrated by combining ASAP with the phase information extracted from lag-1 autocorrelation. The 3-D vascular and velocity mapping of the mouse kidney, liver, and tumor were demonstrated by stacking the ASAP images acquired using 2-D ultrasound imaging and a trigger-controlled linear translation stage. The 3-D results depicted clear microvasculature morphologies and functional information in terms of flow direction and velocity in two nontumor models and a tumor model. In conclusion, we have demonstrated a new 3-D in vivo ultrasound microvascular imaging technique with significantly improved SNR over existing ultrafast Doppler.
机译：考虑到复杂的3D血管网络结构，三维成像对于无创评估血管生成非常有价值。每秒可产生数千张图像的高帧频（HFR）超声的出现激发了新颖的信号处理技术及其在血管结构和功能成像中的应用。尽管已经使用超快多普勒仪证实了高度敏感的血管作图，但是低信噪比（SNR）可能会阻碍背景噪声对微脉管系统的可检测性，特别是在较深的区域并且不使用造影剂。我们最近展示了一种基于相干的技术，即声子孔径成像（ASAP），用于超对比血管成像，并说明了使用HFR增强超声的对比度改善。在这项工作中，我们提供了在不使用造影剂的情况下使用ASAP进行微血管成像的可行性研究，并将其功能从二维扩展到了体积血管测绘。使用超声研究系统和临床前探针，我们证明了与未注射造影剂的小鼠肾脏，肝脏和肿瘤相比，使用ASAP改善了微血管成像的可见度，与超快功率多普勒（PD）相比。与PD相比，ASAP图像的SNR平均提高了10 dB。此外，通过将ASAP与从lag-1自相关提取的相位信息相结合，还演示了方向速度映射。小鼠肾脏，肝脏和肿瘤的3-D血管和速度图谱通过堆叠使用2-D超声成像和触发器控制的线性平移台获得的ASAP图像进行演示。 3-D结果在两个非肿瘤模型和肿瘤模型中根据流动方向和速度描绘了清晰的微脉管系统形态和功能信息。总之，我们已经证明了一种新的3-D体内超声微血管成像技术，与现有的超快多普勒仪相比，SNR显着提高。

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  • 作者

    Leow Chee Hau; Bush Nigel L.; Stanziola Antonio; Braga Marta; Shah Anant; Hernandez-Gil Javier; Long Nicholas J.; Aboagye Eric O.; Bamber Jeffrey C.; Tang Meng-Xing;

  • 作者单位

    Imperial Coll London, Dept Bioengn, London SW7 2AZ, England;

    Inst Canc Res, Joint Dept Phys, London, England|Inst Canc Res, Canc Res UK Canc Imaging Ctr, London, England|Royal Marsden NHS Fdn Trust, London, England;

    Imperial Coll London, Dept Bioengn, London SW7 2AZ, England;

    Imperial Coll London, Comprehens Canc Imaging Ctr, Dept Surg & Canc, Sutton SM2 5NG, Surrey, England;

    Inst Canc Res, Joint Dept Phys, London, England|Inst Canc Res, Canc Res UK Canc Imaging Ctr, London, England|Royal Marsden NHS Fdn Trust, London, England|Natl Phys Lab, Ultrasound & Underwater Acoust, Teddington TW11 0LW, Middx, England;

    Imperial Coll London, Comprehens Canc Imaging Ctr, Dept Surg & Canc, Sutton SM2 5NG, Surrey, England|Imperial Coll London, Dept Chem, London SW7 2AZ, England;

    Imperial Coll London, Comprehens Canc Imaging Ctr, Dept Surg & Canc, Sutton SM2 5NG, Surrey, England|Imperial Coll London, Dept Chem, London SW7 2AZ, England;

    Imperial Coll London, Comprehens Canc Imaging Ctr, Dept Surg & Canc, Sutton SM2 5NG, Surrey, England;

    Inst Canc Res, Joint Dept Phys, London, England|Inst Canc Res, Canc Res UK Canc Imaging Ctr, London, England|Royal Marsden NHS Fdn Trust, London, England;

    Imperial Coll London, Dept Bioengn, London SW7 2AZ, England;

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  • 正文语种 eng
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  • 关键词

    Doppler; microvascular flow; noise reduction; spatio-temporal coherence analysis; volumetric imaging;

    机译：多普勒;微血管流动;降噪;时空连贯性分析;体积成像;

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