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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >3-D Microvascular Imaging Using High Frame Rate Ultrasound and ASAP Without Contrast Agents: Development and Initial In Vivo Evaluation on Nontumor and Tumor Models
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3-D Microvascular Imaging Using High Frame Rate Ultrasound and ASAP Without Contrast Agents: Development and Initial In Vivo Evaluation on Nontumor and Tumor Models

机译：3-D微血管成像使用高帧速率超声和ASAP没有造影剂：开发和初始<斜体>在非肿瘤和肿瘤模型中的体内评价

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摘要

Three-dimensional imaging is valuable to noninvasively assess angiogenesis given the complex 3-D architecture of vascular networks. The emergence of high frame rate (HFR) ultrasound, which can produce thousands of images per second, has inspired novel signal processing techniques and their applications in structural and functional imaging of blood vessels. Although highly sensitive vascular mapping has been demonstrated using ultrafast Doppler, the detectability of microvasculature from the background noise may be hindered by the low signal-to-noise ratio (SNR) particularly in the deeper region and without the use of contrast agents. We have recently demonstrated a coherence-based technique, acoustic subaperture imaging (ASAP), for super-contrast vascular imaging and illustrated the contrast improvement using HFR contrast-enhanced ultrasound. In this work, we provide a feasibility study for microvascular imaging using ASAP without contrast agents, and extend its capability from 2-D to volumetric vascular mapping. Using an ultrasound research system and a preclinical probe, we demonstrated the improved visibility of microvascular mapping using ASAP in comparison to ultrafast power Doppler (PD) on a mouse kidney, liver, and tumor without contrast agent injection. The SNR of ASAP images improves in average by 10 dB when compared to PD. In addition, directional velocity mappings were also demonstrated by combining ASAP with the phase information extracted from lag-1 autocorrelation. The 3-D vascular and velocity mapping of the mouse kidney, liver, and tumor were demonstrated by stacking the ASAP images acquired using 2-D ultrasound imaging and a trigger-controlled linear translation stage. The 3-D results depicted clear microvasculature morphologies and functional information in terms of flow direction and velocity in two nontumor models and a tumor model. In conclusion, we have demonstrated a new 3-D in vivo ultrasound microvascular imaging technique with significantly improved SNR over existing ultrafast Doppler.
机译：在血管网络的复杂3-D结构上，三维成像对非侵入性评估血管生成有价值。高帧速率（HFR）超声的出现，可以每秒产生数千次图像，这是一种新的信号处理技术及其在血管的结构和功能成像中的应用。尽管使用超速多普勒已经证明了高敏感的血管映射，但是从背景噪声中的微血管结构的可检测性可以受到低信噪比（SNR）的阻碍，特别是在更深的区域中并且不使用造影剂。我们最近展示了一种基于一致的技术，声学子射线成像（ASAP），用于超对比血管成像，并使用HFR对比度增强超声说明了对比度改善。在这项工作中，我们提供了尽快使用造影剂的微血管成像的可行性研究，并将其从2-D延伸到体积血管映射的能力。使用超声研究系统和临床前探针，我们证明了与鼠标肾，肝脏和肿瘤上的超快动力多普勒（PD）相比，使用ASAP改善了微血管映射的可见性。没有造影剂注射。与PD相比，ASAP图像的SNR平均提高10dB。此外，还通过与从LAG-1自相关的相位信息组合来证明方向速度映射。通过堆叠使用使用2-D超声成像和触发控制的线性翻译级获得的ASAP图像来证明小鼠肾脏，肝脏和肿瘤的3-D血管和速度映射。 3-D结果在两个无轨模型和肿瘤模型中，在流动方向和速度方面描绘了清晰的微血管形态和功能信息。总之，我们已经证明了一种新的3-D，体内超声微血管成像技术具有显着改善的SNR现有超速多普勒。

著录项

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  • 作者

    Leow Chee Hau; Bush Nigel L.; Stanziola Antonio; Braga Marta; Shah Anant; Hernandez-Gil Javier; Long Nicholas J.; Aboagye Eric O.; Bamber Jeffrey C.; Tang Meng-Xing;

  • 作者单位

    Imperial Coll London Dept Bioengn London SW7 2AZ England;

    Inst Canc Res Joint Dept Phys London England|Inst Canc Res Canc Res UK Canc Imaging Ctr London England|Royal Marsden NHS Fdn Trust London England;

    Imperial Coll London Dept Bioengn London SW7 2AZ England;

    Imperial Coll London Comprehens Canc Imaging Ctr Dept Surg & Canc Sutton SM2 5NG Surrey England;

    Inst Canc Res Joint Dept Phys London England|Inst Canc Res Canc Res UK Canc Imaging Ctr London England|Royal Marsden NHS Fdn Trust London England|Natl Phys Lab Ultrasound & Underwater Acoust Teddington TW11 0LW Middx England;

    Imperial Coll London Comprehens Canc Imaging Ctr Dept Surg & Canc Sutton SM2 5NG Surrey England|Imperial Coll London Dept Chem London SW7 2AZ England;

    Imperial Coll London Comprehens Canc Imaging Ctr Dept Surg & Canc Sutton SM2 5NG Surrey England|Imperial Coll London Dept Chem London SW7 2AZ England;

    Imperial Coll London Comprehens Canc Imaging Ctr Dept Surg & Canc Sutton SM2 5NG Surrey England;

    Inst Canc Res Joint Dept Phys London England|Inst Canc Res Canc Res UK Canc Imaging Ctr London England|Royal Marsden NHS Fdn Trust London England;

    Imperial Coll London Dept Bioengn London SW7 2AZ England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Doppler; microvascular flow; noise reduction; spatio-temporal coherence analysis; volumetric imaging;

    机译：多普勒;微血管流动;降噪;时空连贯性分析;体积成像;

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