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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Spectral Quantification of Nonlinear Elasticity Using Acoustoelasticity and Shear-Wave Dispersion
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Spectral Quantification of Nonlinear Elasticity Using Acoustoelasticity and Shear-Wave Dispersion

机译：基于声弹性和剪切波频散的非线性弹性谱量化

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摘要

Tissue biomechanical properties are known to be sensitive to pathological changes. Accordingly, various techniques have been developed to estimate tissue mechanical properties. Shear-wave elastography (SWE) measures shear-wave speed (SWS) in tissues, which can be related to shear modulus. Although viscosity or stress-strain nonlinearity may act as confounder of SWE, their explicit characterization may also provide additional information about tissue composition as a contrast modality. Viscosity can be related to frequency dispersion of SWS, which can be characterized using multi-frequency measurements, herein called spectral SWE (SSWE). Additionally, nonlinear shear modulus can be quantified and parameterized based on SWS changes with respect to applied stress, a phenomenon called acoustoelasticity (AE). In this work, we characterize the nonlinear parameters of tissue as a function of excitation frequency by utilizing both AE and SSWE together. For this, we apply incremental amounts of quasi-static stress on a medium, while imaging and quantifying SWS dispersion via SSWE. Results from phantom and ex vivo porcine liver experiments demonstrate the feasibility of measuring frequency-dependent nonlinear parameters using the proposed method. SWS propagation in porcine liver tissue was observed to change from 1.8 m/s at 100 Hz to 3.3 m/s at 700 Hz, while increasing by approximately 25 from a strain of 0 to 12 across these frequencies.
机译：已知组织生物力学性质对病理变化敏感。因此，已经开发出各种技术来估计组织的机械性能。剪切波弹性成像（SWE）测量组织中的剪切波速度（SWS），这可能与剪切模量有关。尽管粘度或应力-应变非线性可能会成为SWE的混杂因素，但它们的显式表征也可能提供有关组织组成的其他信息（作为对比方式）。粘度可能与SWS的频散有关，可以使用多频测量（此处称为频谱SWE（SSWE））来表征。此外，可以基于相对于施加应力的SWS变化对非线性剪切模量进行量化和参数化，这种现象称为声弹弹性（AE）。在这项工作中，我们通过同时利用AE和SSWE将组织的非线性参数表征为激发频率的函数。为此，我们在介质上施加增量的准静态应力，同时通过SSWE成像和量化SWS色散。幻像和离体猪肝脏实验的结果证明了使用所提出的方法测量频率依赖性非线性参数的可行性。观察到猪肝组织中SWS的传播从100 Hz时的1.8 m / s变化到700 Hz时的3.3 m / s，而从0到12的应变在这些频率上增加了约25。

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