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Ex Vivo HIFU Experiments Using a 32×32 -Element CMUT Array

机译:使用32×32元素CMUT阵列的体内HIFU实验

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High-intensity focused ultrasound (HIFU) has been used as noninvasive treatment for various diseases. For these therapeutic applications, capacitive micromachined ultrasonic transducers (CMUTs) have advantages that make them potentially preferred transducers over traditional piezoelectric transducers. In this paper, we present the design and the fabrication process of an 8×8 -mm 2 32×32 -element 2-D CMUT array for HIFU applications. To reduce the system complexity for addressing the 1024 transducer elements, we propose to group the CMUT array elements into eight HIFU channels based on the phase delay from the CMUT element to the targeted focal point. Designed to focus at an 8-mm depth with a 5-MHz exciting frequency, this grouping scheme was realized using a custom application-specific integrated circuit. With a 40-V dc bias and a 60-V peak-to-peak ac excitation, the surface pressure was measured 1.2 MPa peak-to-peak and stayed stable for a long enough time to create a lesion. With this dc and ac voltage combination, the measured peak-to-peak output pressure at the focus was 8.5 MPa, which is expected to generate a lesion in a minute according to the temperature simulation. The following ex vivo tissue experiments successfully demonstrated its capability to make lesions in both bovine muscle and liver tissue.
机译:高强度聚焦超声(HIFU)已被用作各种疾病的无创治疗。对于这些治疗应用,电容式微机械超声换能器(CMUT)具有使它们成为优于传统压电换能器的潜在首选换能器的优势。在本文中,我们介绍了用于HIFU应用的8×8 mm 2 32×32元素二维CMUT阵列的设计和制造过程。为了降低寻址1024个换能器元件的系统复杂性,我们建议根据从CMUT元件到目标焦点的相位延迟将CMUT阵列元件分为八个HIFU通道。该分组方案设计为聚焦在8mm深度,激励频率为5MHz,是使用定制的专用集成电路实现的。在40 V直流偏置和60 V峰峰值交流激励下,测得的表面压力峰峰值为1.2 MPa,并在足够长的时间内保持稳定以产生损伤。使用这种直流和交流电压组合,在焦点处测得的峰峰值输出压力为8.5 MPa,根据温度模拟,预计在一分钟内会产生病变。以下离体组织实验成功证明了其在牛肌肉和肝组织中均产生损伤的能力。

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