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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >A preliminary engineering design of intravascular dual-frequency transducers for contrast-enhanced acoustic angiography and molecular imaging
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A preliminary engineering design of intravascular dual-frequency transducers for contrast-enhanced acoustic angiography and molecular imaging

机译：造影剂增强型血管造影和分子成像的血管内双频换能器的初步工程设计

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摘要

Current intravascular ultrasound (IVUS) probes are not optimized for contrast detection because of their design for high-frequency fundamental-mode imaging. However, data from transcutaneous contrast imaging suggests the possibility of utilizing contrast ultrasound for molecular imaging or vasa vasorum assessment to further elucidate atherosclerotic plaque deposition. This paper presents the design, fabrication, and characterization of a small-aperture (0.6 ?? 3 mm) IVUS probe optimized for high-frequency contrast imaging. The design utilizes a dual-frequency (6.5 MHz/30 MHz) transducer arrangement for exciting microbubbles at low frequencies (near their resonance) and detecting their broadband harmonics at high frequencies, minimizing detected tissue backscatter. The prototype probe is able to generate nonlinear microbubble response with more than 1.2 MPa of rarefractional pressure (mechanical index: 0.48) at 6.5 MHz, and is also able to detect microbubble response with a broadband receiving element (center frequency: 30 MHz, ??6-dB fractional bandwidth: 58.6%). Nonlinear super-harmonics from microbubbles flowing through a 200-??m-diameter micro-tube were clearly detected with a signal-to-noise ratio higher than 12 dB. Preliminary phantom imaging at the fundamental frequency (30 MHz) and dual-frequency super-harmonic imaging results suggest the promise of small aperture, dual-frequency IVUS transducers for contrast-enhanced IVUS imaging.
机译：当前的血管内超声（IVUS）探头由于针对高频基本模式成像的设计而并未针对对比度检测进行优化。然而，来自经皮对比成像的数据表明利用对比超声进行分子成像或血管脉管评估的可能性，以进一步阐明动脉粥样硬化斑块的沉积。本文介绍了针对高频对比成像优化的小孔径（0.6 ?? 3 mm）IVUS探头的设计，制造和特性。该设计利用双频（6.5 MHz / 30 MHz）换能器布置来激发低频处的微气泡（在其共振附近）并在高频处检测其宽带谐波，从而将检测到的组织反向散射降至最低。该原型探头能够在6.5 MHz时产生超过1.2 MPa的稀分数（机械指数：0.48）的非线性微气泡响应，并且还能够使用宽带接收元件（中心频率：30 MHz，??）检测微气泡响应。 6 dB的分数带宽：58.6％）。可以清楚地检测到流过直径200 µm的微管的微气泡的非线性超谐波，信噪比高于12 dB。在基频（30 MHz）上的初步幻像成像和双频超谐波成像结果表明，小孔径，双频IVUS换能器可用于增强对比度的IVUS成像。

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