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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Combined perfusion and doppler imaging using plane-wave nonlinear detection and microbubble contrast agents
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Combined perfusion and doppler imaging using plane-wave nonlinear detection and microbubble contrast agents

机译：结合使用平面波非线性检测和微泡造影剂的灌注和多普勒成像

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摘要

Plane-wave imaging offers image acquisition rates at the pulse repetition frequency, effectively increasing the imaging frame rates by up to two orders of magnitude over conventional line-by-line imaging. This form of acquisition can be used to achieve very long ensemble lengths in nonlinear modes such as pulse inversion Doppler, which enables new imaging trade-offs that were previously unattainable. We first demonstrate in this paper that the coherence of microbubble signals under repeated exposure to acoustic pulses of low mechanical index can be as high as 204 ± 5 pulses, which is long enough to allow an accurate power Doppler measurement. We then show that external factors, such as tissue acceleration, restrict the detection of perfusion at the capillary level with linear Doppler, even if long Doppler ensembles are considered. Hence, perfusion at the capillary level can only be detected with ultrasound through combined microbubbles and Doppler imaging. Finally, plane-wave contrast-enhanced power and color Doppler are performed on a rabbit kidney in vivo as a proof of principle. We establish that long pulse-inversion Doppler sequences and conventional wall-filters can create an image that simultaneously resolves both the vascular morphology of veins and arteries, and perfusion at the capillary level with frame rates above 100 Hz.
机译：平面波成像可提供脉冲重复频率下的图像采集速率，与传统的逐行成像相比，可将成像帧速率有效提高多达两个数量级。这种采集形式可用于在非线性模式（例如脉冲反转多普勒）中获得非常长的整体长度，从而实现了以前无法实现的新成像折衷。我们首先在本文中证明，在反复暴露于低机械指数的声脉冲下，微泡信号的相干性可以高达204±5个脉冲，足够长，可以进行精确的功率多普勒测量。然后，我们表明，即使考虑到长的多普勒集合，诸如组织加速之类的外部因素也会限制使用线性多普勒在毛细血管水平上的灌注检测。因此，只有通过超声结合微气泡和多普勒成像才能检测到毛细管水平的灌注。最后，在体内对兔肾脏进行了平面波对比增强功能和彩色多普勒检测，以此作为原理性证明。我们建立了长脉冲反转多普勒序列和常规壁滤器可以创建图像，该图像同时解析静脉和动脉的血管形态以及在毛细血管水平上以高于100 Hz的速率进行灌注。

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