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Experimental evaluation of photoacoustic coded excitation using unipolar golay codes

机译:使用单极格雷码进行光声编码激发的实验评估

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摘要

Q-switched Nd:YAG lasers are commonly used as light sources for photoacoustic imaging. However, laser diodes are attractive as an alternative to Nd:YAG lasers because they are less expensive and more compact. Although laser diodes deliver about three orders of magnitude less light pulse energy than Nd:YAG lasers (tens of microjoules compared with tens of millijoules), their pulse repetition frequency (PRF) is four to five orders of magnitude higher (up to 1 MHz compared with tens of hertz); this enables the use of averaging to improve SNR without compromising the image acquisition rate. In photoacoustic imaging, the PRF is limited by the maximum acoustic time-of-flight. This limit can be overcome by using coded excitation schemes in which the coding eliminates ambiguities between echoes induced by subsequent pulses. To evaluate the benefits of photoacoustic coded excitation (PACE), the performance of unipolar Golay codes is investigated analytically and validated experimentally. PACE imaging of a copper slab using laser diodes at a PRF of 1 MHz and a modified clinical ultrasound scanner is successfully demonstrated. Considering laser safety regulations and taking into account a comparison between a laser diode system and Nd:YAG systems with respect to SNR, we conclude that PACE is feasible for small animal imaging.
机译:调Q Nd:YAG激光器通常用作光声成像的光源。但是,激光二极管作为Nd:YAG激光器的替代品很有吸引力,因为它们价格便宜且结构紧凑。尽管激光二极管提供的光脉冲能量比Nd:YAG激光少大约三个数量级(几十微焦耳相比几十毫焦耳),但它们的脉冲重复频率(PRF)高四到五个数量级(与之相比,最高1 MHz)几十赫兹);这样就可以使用平均值来改善SNR,而不会影响图像采集速率。在光声成像中,PRF受最大声波飞行时间限制。通过使用编码的激励方案可以克服此限制,在该方案中,编码消除了后续脉冲引起的回波之间的歧义。为了评估光声编码激发(PACE)的好处,对单极Golay码的性能进行了分析研究和实验验证。使用激光二极管以1 MHz的PRF和改进的临床超声扫描仪成功地演示了铜板的PACE成像。考虑到激光安全法规,并考虑到激光二极管系统和Nd:YAG系统之间在信噪比方面的比较,我们得出结论,PACE对于小型动物成像是可行的。

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