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Identification of vulnerable atherosclerotic plaque using IVUS-based thermal strain imaging

机译:基于IVUS的热应变成像识别易损的动脉粥样硬化斑块

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Pathology and autopsy studies have demonstrated that sudden disruption of vulnerable atherosclerotic plaque is responsible for most acute coronary syndromes. These plaques are characterized by a lipid-rich core with abundant inflammatory cells and a thin fibrous cap. Thermal strain imaging (TSI) using intravascular ultrasound (IVUS) has been proposed for high-risk arterial plaque detection, in which image contrast results from the temperature dependence of sound speed. It has the potential to distinguish a lipid-laden lesion from the arterial vascular wall due to its strong contrast between water-bearing and lipid-bearing tissue. Initial simulations indicate plaque identification is possible for a 1/spl deg/C temperature rise. A phantom experiment using an IVUS imaging array further supports the concept, and results agree reasonably well with prediction.
机译:病理和尸检研究表明,易碎的动脉粥样硬化斑块的突然破坏是造成大多数急性冠脉综合征的原因。这些斑块的特征是富含脂质的核心具有丰富的炎症细胞和薄的纤维帽。已经提出使用血管内超声(IVUS)的热应变成像(TSI)用于高风险动脉斑块检测,其中图像对比度由声速的温度依赖性产生。由于它在含水组织和脂质组织之间的强烈反差,因此有可能从动脉血管壁中区分出脂质过多的病变。最初的模拟表明,对于温度为1 / spl deg / C的上升,噬菌斑识别是可能的。使用IVUS成像阵列的幻像实验进一步支持了这一概念,并且结果与预测相当吻合。

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