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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Characteristics of acoustic scattering from a double-layered micro shell for encapsulated drug delivery
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Characteristics of acoustic scattering from a double-layered micro shell for encapsulated drug delivery

机译：用于包装药物的双层微壳的声散射特性

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摘要

This work examines the characteristic differences in acoustic scattering between air-filled double-layered encapsulating (DLE) shells and air-filled single-layered encapsulating (SLE) shells. The analysis shows that the presence of an outer layer softer than the inner layer results in a shift of the first monopole of the reflectivity-frequency response to a higher frequency and a reduction in the monopole peak; and it leads to a frequency-separation of the two dipoles that trace the monopole. The frequency shift and the peak reduction of the monopole and the frequency separation of the two dipoles all increase with the increasing thickness of the softer outer layer. The numerical results reveal that variations in the Lame constant of the model material for the protein albumin have little effect on the low-frequency scattering characteristics, while they affect the high-frequency scattering characteristics significantly. The authors have shown that this phenomenon is due to the fact that the model material for the protein albumin has a Lame constant substantially larger than its shear modulus. Their further numerical studies conclude that, for each DLE shell, one can construct an equivalent SLE shell, using a simple scheme originated from the mechanics of composite materials in the sense that the so-constructed SLE shell has essentially the same acoustic scattering characteristics as the DLE shell within a low frequency range.
机译：这项工作研究了充气双层封装（DLE）外壳和充气单层封装（SLE）外壳之间的声学​​散射特性差异。分析表明，存在一个比内层更软的外层，会导致反射率-频率响应的第一个单极子向更高的频率偏移，并降低单极子峰。并导致追踪单极子的两个偶极子发生频率分离。单极子的频移和峰值减小以及两个偶极子的频率分离都随着较软外层厚度的增加而增加。数值结果表明，蛋白白蛋白模型材料的拉梅常数的变化对低频散射特性影响很小，而对高频散射特性有很大影响。作者已经表明，这种现象是由于蛋白质白蛋白的模型材料的Lame常数明显大于其剪切模量而造成的。他们进一步的数值研究得出的结论是，对于每个DLE壳，可以使用一种源自复合材料力学的简单方案来构造等效的SLE壳，因为如此构造的SLE壳具有与DLE壳基本相同的声散射特性。 DLE外壳在低频范围内。

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