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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Behavioral and Functional Assessment of Ultrasound Neuromodulation on Caenorhabditis Elegans
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Behavioral and Functional Assessment of Ultrasound Neuromodulation on Caenorhabditis Elegans

机译：皮诺菌杆菌超声神经调节的行为与功能评估

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摘要

Ultrasound brain stimulation is a promising modality for probing brain function and treating brain diseases. However, its mechanism is as yet unclear, and in vivo effects are not well-understood. Here, we present a top-down strategy for assessing ultrasound bioeffects in vivo, using Caenorhabditis elegans. Behavioral and functional changes of single worms and of large populations upon ultrasound stimulation were studied. Worms were observed to significantly increase their average speed upon ultrasound stimulation, adapting to it upon continued treatment. Worms also generated more reversal turns when ultrasound was ON, and within a minute post-stimulation, they performed significantly more reversal and omega turns than prior to ultrasound. In addition, in vivo calcium imaging showed that the neural activity in the worms' heads and tails was increased significantly by ultrasound stimulation. In all, we conclude that ultrasound can directly activate the neurons of worms in vivo, in both of their major neuronal ganglia, and modify their behavior.
机译：超声脑刺激是探测脑功能和治疗脑病的有希望的模态。然而，其机制尚不清楚，体内效应并不熟知。在这里，我们提出了一种自上而下的策略，用于评估体内超声生物效应，使用Caenorhabditis elegans。研究了单一蠕虫的行为和功能变化以及大量群体超声刺激。观察到蠕虫在超声刺激后显着提高平均速度，在继续治疗时适应它。当超声波接通时，蠕虫也产生了更多的反转转弯，并且在刺激后的一分钟内，它们比超声波之前的逆转和ω变动显着更高。此外，体内钙成像表明，通过超声波刺激显着增加了蠕虫头和尾部的神经活动。总而言之，我们得出结论，超声波可以直接在其主要神经元神经节的体内激活蠕虫的神经元，并改变其行为。

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