Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus

S. Consuegra; H. J. Megens; K. Leon; R. J. M. Stet; W. C. Jordan

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Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus

机译：大西洋鲑鱼主要组织相容性II类α基因座处的变异型与I类基因座处的变异性形成对比

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In order to investigate the mechanisms creating and maintaining variability at the major histocompatibility (MH) class II alpha (DAA) locus we examined patterns of polymorphism in two isolated Atlantic salmon populations which share a common post-glacial origin. As expected from their common origin, but contrary to the observation at the MH class I locus, these populations shared the majority of DAA alleles: out of 17 sequences observed, 11 were common to both populations. Recombination seems to play a more important role in the origin of new alleles at the class II alpha locus than at the class I locus. A greater than expected proportion of sites inferred to be positively selected (potentially peptide binding residues, PBRs) were found to be involved in recombination events, suggesting a mechanism for increasing MH variability through an interaction between recombination and natural selection. Thus it appears that although selection and recombination are important mechanisms for the evolution of both class II alpha and class I loci in the Atlantic salmon, the pattern of variability differs markedly between these classes of MH loci.

机译：为了研究在主要组织相容性（MH）II类阿尔法（DAA）基因座处形成和维持变异性的机制，我们研究了两个分离的大西洋鲑鱼种群的多态性模式，这些鲑鱼种群具有共同的冰川后起源。正如从其共同起源所期望的那样，但与在MH I类基因座处观察到的相反，这些种群共有大多数DAA等位基因：在观察到的17个序列中，两个种群共有11个。与II类基因座相比，重组似乎在II类α基因座的新等位基因的起源中起着更重要的作用。发现比预期大得多的被推断为阳性选择的位点（可能是肽结合残基，PBR）参与重组事件，这表明通过重组和自然选择之间的相互作用增加MH变异性的机制。因此看来，尽管选择和重组是在大西洋鲑中进化II类α和I类基因座的重要机制，但是在这些类别的MH基因座之间，变异性的模式明显不同。

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《Immunogenetics》 |2005年第2期|16-24|共9页
作者
S. Consuegra; H. J. Megens; K. Leon; R. J. M. Stet; W. C. Jordan;
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作者单位

Institute of Zoology Zoological Society of LondonPresent address: Fish Muscle Research Group Gatty Marine Laboratory University of St Andrews;

Cell Biology and Immunology Group Department of Animal Sciences Wageningen University;

Cell Biology and Immunology Group Department of Animal Sciences Wageningen University;

Cell Biology and Immunology Group Department of Animal Sciences Wageningen UniversityPresent address: Scottish Fish Immunology Research Centre University of Aberdeen;

Institute of Zoology Zoological Society of London;

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正文语种 eng
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关键词
MHC; Class II alpha; Recombination; Natural selection; Atlantic salmon;

机译：MHC;II类alpha;重组;自然选择;大西洋鲑鱼;

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2. The major histocompatibility class I locus in Atlantic salmon (Salmo salar L.): polymorphism, linkage analysis and protein modelling [J] . Unni Grimholt, Finn Drabløs, Sven Jørgensen, Immunogenetics . 2002,第8期

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3. Contrasting responses to selection in class I and class IIalpha major histocompatibility-linked markers in salmon. [J] . Consuegra S, de Eyto E, McGinnity P, Heredity: An International Journal of Genetics . 2011,第2期

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4. Prediction and Rule Extraction of Major Histocompatibility Complex Class II Epitopes by Logic Minimization [C] . C. Aguilar-Bonavides, R. Cruz-Cano, C. Lanzas International Conference on Bioinformatics and Computational Biology . 2014

机译：逻辑最小化主要组织相容性复合物类别表位的预测与规则提取
5. Defining the mechanism of MHC class II peptide editing by HLA-DM: I. HLA-DM recognizes the flexible conformation of major histocompatibility complex class II. II. Mapping the interaction surface of DR1 with DM by superantigen blocking. III. Determinati [D] . Chou, Chih-Ling. 2003

机译：定义HLA-DM编辑MHC II类肽的机制：I. HLA-DM识别II类主要组织相容性复合物的柔性构象。二。通过超抗原阻断作用绘制DR1与DM的相互作用表面。三，确定性
6. The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule [O] . 1991

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7. Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus [O] . Consuegra S., Megens H.J.W.C., Leon K.M., 2005

机译：大西洋鲑鱼主要组织相容性II类α基因座处的变异型与I类基因座处的变异性形成对比

Patterns of variability at the major histocompatibility class II alpha locus in Atlantic salmon contrast with those at the class I locus

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