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首页> 外文期刊>Indian Journal of Pediatrics >Salbutamol and/or beclomethasone diproprionate in asthma
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Salbutamol and/or beclomethasone diproprionate in asthma

机译：沙丁胺醇和/或倍氯米松双丙酸酯治疗哮喘

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Objective: Acute severe exacerbation of asthma is potentially life threatening and requires critical assessment and appropriate therapy. Now a days, steroids are often combined with bronchodilators for the treatment of bronchial asthma. Therefore, the present study was undertaken to compare effectiveness of beclomethasone diproprionate-salbutamol combination versus salbutamol alone by MDI (with or without spacer) in acute asthma.Methods : A total of 57 paediatric patients (5–12 years) with acute attack of bronchial asthma attending emergency department of Indira Gandhi Medical College and Hospital was randomised to receive salbutamol (100 μg/puff) alone or with BDP (50 μg/puff) by metered dose inhaler with or without spacer. All baseline investigations were repeated one hour after the therapy.Results : Clinical parameters indicative of severity of asthma improved statistically in all treatment groups. The increase in PEFR was better with MDI-S+B with spacer as compared to other groups, though it failed to reach statistical significance. The fall in serum potassium level is significantly more with MDI-S+B group when spacer was not used. No serious adverse effects were observed in any of the treatment groups.Conclusions. Metered dose inhalation of BDP-salbutamol combination with spacer provides better recovery whereas fall in serum potassium with MDI-S+B suggests use of spacer and monitoring of serum potassium during treatment. Key words Bronchial asthma - Salbutamol - Beclomethasone diproprionate - Metered dose inhaler
机译：目的：急性严重哮喘发作可能危及生命，需要进行严格的评估和适当的治疗。如今，类固醇通常与支气管扩张剂联合用于治疗支气管哮喘。因此，本研究旨在比较MDI（有或无间隔药）联合倍氯米松双丙酸-沙丁胺醇联合沙丁胺醇单独使用或联合使用沙丁胺醇在急性哮喘中的有效性。方法：共有57例小儿（5-12岁）患有支气管急性发作由英迪拉·甘地医学院和医院急诊科就诊的哮喘患者被随机分配接受沙丁胺醇（100μg/粉扑）或与BDP（50μg/粉扑）一起通过带或不带有间隔物的定量吸入器接受。治疗后一小时，重复所有基线研究。结果：在所有治疗组中，指示哮喘严重程度的临床参数均有统计学改善。与其他组相比，带有间隔物的MDI-S + B的PEFR升高更好，尽管未能达到统计学显着性。当不使用间隔子时，MDI-S + B组的血清钾水平下降明显更多。在任何治疗组中均未观察到严重的不良反应。 BDP-沙丁胺醇与间隔物的定量吸入可提供更好的恢复，而MDI-S + B可使血清钾下降，建议在治疗期间使用间隔物并监测血清钾。关键词支气管哮喘-沙丁胺醇-双丙酸倍氯米松-计量吸入器

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