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首页> 外文期刊>Indian Journal of Pediatrics >Reduced exercise capacity in non-cystic fibrosis bronchiectasis
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Reduced exercise capacity in non-cystic fibrosis bronchiectasis

机译：非囊性纤维化支气管扩张症的运动能力下降

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Objective : Bronchiectasis not due to cystic fibrosis is usually a consequence of severe bacterial or tuberculous infection of the lungs, which is commonly seen in children in developing countries. Our aim was to study its functional sequelae and affect on work capacity in children.Methods : Seventeen children (7-17 years of age) with clinical and radiological evidence of bronchiectasis of one or both lungs were studied at the Cardiopulmonary Unit of the Tuberculosis Research Centre. Pulmonary function tests including spirometry and lung volume measurements were performed. Incremental exercise stress test was done on a treadmill, and ventilatory and cardiac parameters were monitored. Control values were taken from a previous study.Results : Children with bronchiectasis had lower forced vital capacity (FVC) (1.1 + 0.4 L versus 1.5 + 0.4 L, p=0.003) and FEV, (0.95 ±0.2 L versus 1.4 ±0.3 L, p<0.002) compared to age- and sex-matched healthy controls. The patient group had significantly higher residual lung volumes (0.7 ±0.3 L versus 0.4 + 0.1 L, p<0.02). At maximal exercise, they had lower aerobic capacity (28 +- 6 ml/min/kg versus 38 ±5 ml/min/kg, p<0.0001) and maximal ventilation (24 ±8 L/min versus 39 ±10 L/min, p<0.001). At maximal exercise, while none of the controls desaturated, oxygen saturation fell below 88% in eight of 17 patients.Conclusion : The findings show that children and adolescents with non-cystic fibrosis bronchiectasis have abnormal pulmonary function and reduced exercise capacity. This is likely to interfere with their life as well as future work capacity. Efforts should be made to minimize lung damage in childhood by ensuring early diagnosis and instituting appropriate treatment of respiratory infections. Key words Bronchiectasis - Exercise limitation - Aerobic capacity - Children - Pulmonary function
机译：目的：不是由囊性纤维化引起的支气管扩张通常是严重的肺部细菌或结核感染的结果，这在发展中国家的儿童中很常见。我们的目的是研究其功能性后遗症及其对儿童工作能力的影响。方法：在结核研究中心心肺科研究了17名7-12岁的儿童，其中有一项临床或放射学证据表明一肺或双肺支气管扩张。中央。进行肺功能测试，包括肺活量测定和肺容量测量。在跑步机上进行增量运动压力测试，并监测通气和心脏参数。结果：支气管扩张患儿的强制肺活量（FVC）（1.1 + 0.4 L对1.5 + 0.4 L，p = 0.003）和FEV（0.95±0.2 L对1.4±0.3 L）较低，p <0.002）与年龄和性别相匹配的健康对照组进行比较。患者组的残余肺容积明显更高（0.7±0.3 L对0.4 + 0.1 L，p <0.02）。在进行最大程度的运动时，他们的有氧运动能力较低（28±6 ml / min / kg对38±5 ml / min / kg，p <0.0001），最大通气量（24±8 L / min对39±10 L / min） ，p ＜0.001）。在最大程度地运动时，尽管没有一个对照能够饱和，但17名患者中有8名的氧饱和度降至88％以下。结论：研究结果表明，患有非囊性纤维化支气管扩张的儿童和青少年肺功能异常，运动能力降低。这可能会影响他们的生活以及未来的工作能力。应通过确保及早诊断并适当治疗呼吸道感染，努力将儿童期的肺部损害降至最低。关键词支气管扩张-运动限制-有氧运动能力-儿童-肺功能

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