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首页> 外文期刊>Indian Journal of Pediatrics >Serum IgG levels to bovine insulin in type I diabetes mellitus
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Serum IgG levels to bovine insulin in type I diabetes mellitus

机译：I型糖尿病患者血清IgG对牛胰岛素的水平

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Objectives: This study was undertaken to determine humoral immune response to bovine insulin in Iranian children with type 1 diabetes mellitus.Methods: Serum samples were taken from 93 children aged 4–17 years with type I diabetes mellitus from two centers in Iran (the Iranian Association of Diabetes in Tehran and Center for Diabetes Research in Hamedan), 17 apparently healthy siblings of the diabetic patients (related controls), 28 apparently healthy age- and sex-matched controls (unrelated controls), 14 patients aged 11–15 years with auto-immune thyroiditis, and 45 patients with type II diabetes (aged 44–68 years). Samples were then examined for specific IgG to bovine insulin by enzyme-linked immunosorbent assay (ELISA). A questionnaire on medical history, duration of exclusive and non-exclusive breast feeding and daily intake of dairy products was completed before bleeding.Results: Duration of exclusive and non-exclusive breast-feeding showed no significant difference between patients with type I diabetes, related and unrelated controls and thyroid patients. Diabetic children, however, had significantly higher serum levels of anti-bovine insulin IgG than did unrelated and related healthy controls and patients with type II diabetes (P < 0.01). There was no significant difference between healthy siblings of diabetic children and unrelated controls. In type I diabetic patients and their healthy siblings, serum levels of IgG to bovine insulin were inversely correlated with the duration of non-exclusive breast feeding (rs= -0.37, P= 0.016 and rs -0.53, P= 0.049, respectively). There was no con-elation between serum levels of IgG to bovine insulin with daily intake of dairy products. Bovine insulin cross-reacted with human insulin as judged by ELISA inhibition assay.Conclusion: The emergence of anti-insulin antibodies in Iranian patients with type I DM, which is associated with the duration of breast-feeding is less likely to be due to early exposure of infants with the proteins found in cow’s milk. One speculation could be that the production of antibodies to insulin in type I diabetes may just be a physiologic response (probably to increase the half-life of the circulating insulin). The importance of anti-insulin antibodies in type I diabetes mellitus needs further studies. Key words Serum IgG - Bovine insulin - Cow’s milk - Type I diabetes
机译：目的：本研究旨在确定伊朗1型糖尿病儿童对牛胰岛素的体液免疫反应。方法：从伊朗两个中心（伊朗人）的93名4-17岁I型糖尿病儿童中抽取血清。德黑兰糖尿病协会和Hamedan糖尿病研究中心），糖尿病患者的17名明显健康的兄弟姐妹（相关对照），年龄和性别相匹配的健康对照的28名患者（无关对照），年龄11-15岁的14名患者自身免疫性甲状腺炎和45例II型糖尿病患者（年龄44-68岁）。然后通过酶联免疫吸附测定（ELISA）检查样品中牛胰岛素的特异性IgG。在出血前完成了关于病史，独家和非独家母乳喂养的持续时间以及乳制品每日摄入量的调查问卷。结果：独家和非独家母乳喂养的持续时间表明，I型糖尿病患者之间无显着差异，相关以及无关的对照组和甲状腺患者。然而，糖尿病儿童的抗牛胰岛素IgG血清水平显着高于无关和相关健康对照者和II型糖尿病患者（P <0.01）。糖尿病儿童的健康同胞与无关对照组之间无显着差异。在I型糖尿病患者及其健康兄弟姐妹中，牛胰岛素血清的IgG水平与非排他性母乳喂养的时间呈负相关（r s = -0.37，P = 0.016和r s -0.53，P = 0.049）。每天摄入乳制品之间，血清IgG水平与牛胰岛素水平之间没有相关性。通过ELISA抑制试验判断牛胰岛素与人胰岛素发生交叉反应。结论：伊朗I型DM患者抗胰岛素抗体的出现与母乳喂养的持续时间有关，不太可能是由于早期婴儿暴露于牛奶中发现的蛋白质。一种推测可能是I型糖尿病患者胰岛素抗体的产生可能只是一种生理反应（可能会增加循环胰岛素的半衰期）。抗胰岛素抗体在I型糖尿病中的重要性需要进一步研究。关键词血清IgG-牛胰岛素-牛奶-I型糖尿病

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