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Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort

机译:ECRHS队列中哮喘和非哮喘成年人的家庭中的微生物特征

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摘要

Microbial exposures in homes of asthmatic adults have been rarely investigated; specificities and implications for respiratory health are not well understood. The objectives of this study were to investigate associations of microbial levels with asthma status, asthma symptoms, bronchial hyperresponsiveness (BHR), and atopy. Mattress dust samples of 199 asthmatics and 198 control subjects from 7 European countries participating in the European Community Respiratory Health Survey II study were analyzed for fungal and bacterial cell wall components and individual taxa. We observed trends for protective associations of higher levels of mostly bacterial markers. Increased levels of muramic acid, a cell wall component predominant in Gram-positive bacteria, tended to be inversely associated with asthma (OR’s for different quartiles: II 0.71 [0.39-1.30], III 0.44 [0.23-0.82], and IV 0.60 [0.31-1.18] P for trend .07) and with asthma score (P for trend .06) and with atopy (P for trend .02). These associations were more pronounced in northern Europe. This study among adults across Europe supports a potential protective effect of Gram-positive bacteria in mattress dust and points out that this may be more pronounced in areas where microbial exposure levels are generally lower.
机译:很少研究哮喘成年人家庭中的微生物暴露。呼吸道健康的特异性和含义尚不十分清楚。这项研究的目的是调查微生物水平与哮喘状态,哮喘症状,支气管高反应性(BHR)和特应性的关系。参加欧洲共同体呼吸健康调查II研究的7个欧洲国家的199名哮喘病患者和198名对照受试者的床垫灰尘样品进行了真菌和细菌细胞壁成分以及单个分类群的分析。我们观察到了大多数细菌标记物含量较高的保护性关联趋势。村级酸(革兰氏阳性细菌中主要的细胞壁成分)水平升高,往往与哮喘呈负相关(不同四分位数的OR值:II 0.71 [0.39-1.30],III 0.44 [0.23-0.82]和IV 0.60 [ [0.31-1.18] P代表趋势.07),哮喘评分(P代表趋势.06),特应性哮喘(P代表趋势.02)。这些关联在北欧更为明显。这项在欧洲各地成年人中进行的研究支持了革兰氏阳性细菌对床垫灰尘的潜在保护作用,并指出在微生物暴露水平通常较低的地区,这种作用可能更为明显。

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  • 来源
    《Indoor Air》 |2018年第1期|16-27|共12页
  • 作者单位

    Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland,Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland;

    Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland;

    Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland,Department of Public Health, University of Helsinki, Helsinki, Finland;

    ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,Universitat Pompeu Fabra (UPF), Barcelona, Spain,CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain;

    Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland;

    ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,Universitat Pompeu Fabra (UPF), Barcelona, Spain,CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain;

    Centre for Environment and Health – Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium,Research Foundation Flanders (FWO), Brussels, Belgium;

    Head Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland,Department of Public Health, University of Basel, Basel, Switzerland;

    Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden;

    Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden;

    Department of Medical Sciences, Uppsala University, Uppsala, Sweden;

    CHU de Grenoble Alpes, INSERM U 1209, Université Grenoble Alpes, Grenoble, France;

    Department of Respiratory Medicine and Sleep, Landspitali University Hospital (E7), Reykjavik, Iceland,Faculty of Medicine, University of Iceland, Reykjavik, Iceland;

    Population Health and Occupational Disease, Imperial College, National Heart and Lung Institute, London, UK,MRC-PHE Centre for Environment and Health, Imperial College, London, UK;

    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich, Ludwig Maximillians University Munich, Member of German Center for Lung Research (DZL), Munich, Germany,Institute of Epidemiology I, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany;

    Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    asthma; atopy; bacteria; fungi; microbial exposure;

    机译:哮喘;特应性菌;菌类;微生物暴露;

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