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首页> 外文期刊>Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) >Biofilms in Skin Infections: Propionibacterium acnes and Acne Vulgaris
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Biofilms in Skin Infections: Propionibacterium acnes and Acne Vulgaris

机译：皮肤感染中的生物膜：痤疮丙酸杆菌和寻常痤疮

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摘要

It is generally accepted that many human infections are biofilm-related and that sessile (biofilm-grown) cells are highly resistant against antimicrobial agents. Propionibacterium acnes plays a role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles and it has been suggested that P. acnes cells residing within the follicles grow as a biofilm. Although P. acnes biofilms have not been observed directly in the pilosebaceous unit, the observation that P. acnes readily forms biofilm in vitro as well as on various medical devices in vivo, combined with the high resistance of sessile P. acnes cells and the increased production of particular virulence factors and qourum sensing molecules in sessile cells point in this direction. In addition, in vitro and in vivo biofilm formation has also been demonstrated for other microorganisms involved in skin diseases (including Staphylococcus aureus and Streptococcus pyogenes).
机译：人们普遍认为，许多人类感染是与生物膜相关的，并且无柄（生物膜生长的）细胞对抗菌剂具有高度抵抗力。痤疮丙酸杆菌在寻常痤疮的发病机理中起作用，痤疮是痤疮的毛囊皮脂囊的常见疾病，并且已经提出，驻留在毛囊中的痤疮丙酸杆菌细胞以生物膜的形式生长。尽管痤疮丙酸杆菌的生物膜尚未直接在皮脂腺单位中观察到，但发现痤疮丙酸杆菌容易在体外以及在各种医疗设备上形成生物膜，同时还伴随着无柄痤疮丙酸杆菌细胞的高耐药性和增加无毒细胞中特定毒力因子的产生和qourum感应分子都指向这个方向。此外，还证明了与皮肤疾病有关的其他微生物（包括金黄色葡萄球菌和化脓性链球菌）的体外和体内生物膜形成。

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