Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine

Jianfeng Zhang De-chu C. Tang

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Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine

机译：大肠杆菌颗粒过量生产病原体衍生抗原作为一种简单的疫苗接种方式在进化医学中的局部应用

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The development of a new generation of vaccines that can be produced rapidly at low costs and massadministered noninvasively by non-medical personnel is crucial for boosting vaccine coverage in response to an escalation in demand. The demonstration that topical application of bioengineered nonreplicating Escherichia coli particles overproducing pathogen-derived antigens can mobilize the immune repertoire toward beneficial immune protection against relevant pathogens holds promise for enabling mass-immunization without pain, fear and perceivable tissue damage. Moreover, this noninvasive regimen using E. coli epitopes as a natural adjuvant is in compliance with evolutionary medicine.

机译：可以低成本快速生产并由非医务人员进行非侵入性大规模施用的新一代疫苗的开发对于响应需求的增长而提高疫苗覆盖率至关重要。过度使用病原体衍生抗原的生物工程非复制型大肠杆菌颗粒的局部应用可以动员免疫系统对相关病原体进行有益的免疫保护，这一证明有望实现大规模免疫而不会造成疼痛，恐惧和可察觉的组织损伤。此外，这种使用大肠杆菌表位作为天然佐剂的非侵入性疗法符合进化医学。

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来源
《Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)》 |2008年第3期|p.189-194|共6页
作者
Jianfeng Zhang De-chu C. Tang;
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作者单位

Vaxin Inc., 1500 First Avenue North, Birmingham, Alabama 35203, USA.;

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正文语种 eng
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Skin, stratum corneum, Escherichia coli, γ-irradiation, noninvasive vaccine, epicutaneous immunization;

机译：皮肤;角质层;大肠杆菌;γ射线照射;无创疫苗;表皮免疫;

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专利

1. Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine [J] . Jianfeng Zhang, De chu C. Tang Infectious disorders drug targets . 2008,第3期

机译：大肠杆菌颗粒过量生产病原体衍生抗原作为简单疫苗接种方式在进化医学中的局部应用
2. Topical Application of Escherichia coli-Vectored Vaccine as a Simple Method for Eliciting Protective Immunity [J] . Jianfeng Zhang, Zhongkai Shi, Fan-kun Kong, Infection and immunity . 2006,第6期

机译：大肠杆菌载体疫苗的局部应用作为消除保护性免疫的简单方法
3. Hepatitis B Virus Core Antigen: Enhancement of Its Production in Escherichia coli, and Interaction of the Core Particles with the Viral Surface Antigen [J] . Wen Siang Tan, Michael R. Dyson, Kenneth Murray Biological chemistry . 2003,第3期

机译：乙型肝炎病毒核心抗原：增强其在大肠杆菌中的生产，以及核心颗粒与病毒表面抗原的相互作用
4. Correlates of protection in response to mucosal vaccination with uropathogenic Escherichia coli antigens and the role of IL-17A during urinary tract infection. [D] . Sivick, Kelsey Elizabeth. 2010

机译：与泌尿致病性大肠杆菌抗原的粘膜疫苗接种反应相关的保护作用和尿道感染期间IL-17A的作用。
5. Topical Application of Escherichia coli-Vectored Vaccine as a Simple Method for Eliciting Protective Immunity [O] . Jianfeng Zhang, Zhongkai Shi, Fan-kun Kong, 2006

机译：大肠杆菌载体疫苗的局部应用作为消除保护性免疫的简单方法
6. Topical Application of Escherichia coli-Vectored Vaccine as a Simple Method for Eliciting Protective Immunity [O] . Zhang, Jianfeng, Shi, Zhongkai, Kong, Fan-kun, 2006

机译：大肠杆菌载体疫苗的局部应用作为消除保护性免疫的简单方法
7. Oral Vaccination of Monkeys with an Invasive Escherichia coli K-12 Hybrid Expressing Shigella flexneri 2a Somatic Antigen. [R] . Formal, S. B., Hale, T. L., Kapfer, C., 1984

机译：用表达弗氏志贺氏菌2a体细胞抗原的侵入性大肠杆菌K-12杂交体口服接种猴子。

Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine

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