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首页> 外文期刊>Inflammation >Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase
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Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase

机译：1-磷酸鞘氨醇减轻小鼠肠缺血/再灌注引起的肺损伤：诱导型一氧化氮合酶的作用

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摘要

Multiple organ failure, including acute lung injury (ALI), is a common complication of intestinal ischemia/reperfusion (I/R) injuries and contributes to its high mortality rate. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that enhances vascular barrier function and has anti-inflammatory effects. In the current study, we investigated the effect of S1P on lung injury induced by intestinal I/R. Mice were randomly assigned to one of the following groups: (1) sham-operated mice, (2) mice exposed to superior mesenteric artery occlusion for 45 min followed by reperfusion for 6 h, or (3) mice exposed to I/R that received S1P (100 μg/kg, administered by peritoneal injection). S1P markedly attenuated lung injury, manifested by the improvement of histological changes and significant decreases of lung water content. Moreover, S1P markedly reduced MDA levels and MPO activity in the lung tissues, and plasma levels of proinflammatory cytokines. In addition, S1P treatment significantly suppressed NO generation accompanied by down-regulation of iNOS expression. The results indicate that S1P has a protective effect on lung injury induced by I/R, which may be related to its suppression of iNOS-induced NO generation. S1P seems to be an effective therapeutic agent for intestinal I/R-related lung injury.
机译：多器官衰竭，包括急性肺损伤（ALI），是肠缺血/再灌注（I / R）损伤的常见并发症，并导致其高死亡率。 1-磷酸鞘氨醇（S1P）是一种生物活性鞘脂，可增强血管屏障功能并具有抗炎作用。在当前的研究中，我们调查了S1P对肠I / R诱导的肺损伤的影响。将小鼠随机分为以下一组：（1）假手术小鼠，（2）肠系膜上动脉闭塞45分钟，再灌注6 h，或（3）暴露于I / R的小鼠接受S1P（100μg/ kg，通过腹膜注射给药）。 S1P明显减轻了肺损伤，表现为组织学改变的改善和肺水含量的显着降低。此外，S1P显着降低了肺组织中的MDA水平和MPO活性，并降低了促炎细胞因子的血浆水平。此外，S1P处理显着抑制了NO生成，同时下调了iNOS表达。结果表明，S1P对I / R引起的肺损伤具有保护作用，可能与其抑制iNOS诱导的NO生成有关。 S1P似乎是肠I / R相关性肺损伤的有效治疗剂。

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  • 来源
    《Inflammation》 |2012年第1期|p.158-166|共9页
  • 作者

    Renyu Ding; Jiali Han; Yu Tian; Renxuan Guo; Xiaochun Ma;

  • 作者单位

    Department of Intensive Care Unit, The First Affiliated Hospital of China Medical University, Bei-er Rd 92, Shenyang, 110001, Liaoning Province, China;

    Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, China;

    Department of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China;

    Department of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China;

    Department of Intensive Care Unit, The First Affiliated Hospital of China Medical University, Bei-er Rd 92, Shenyang, 110001, Liaoning Province, China;

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  • 正文语种 eng
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  • 关键词

    acute lung injury; ischemia/reperfusion; reperfusion injury; sphingosine-1-phosphate; nitric-oxide synthase;

    机译：急性肺损伤;缺血/再灌注;再灌注损伤;1-磷酸鞘氨醇;一氧化氮合酶;

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