Asthma and Dehydroepiandrosterone (DHEA): Facts and Hypotheses

Alicja Kasperska-Zajac

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Asthma and Dehydroepiandrosterone (DHEA): Facts and Hypotheses

机译：哮喘和脱氢表雄酮（DHEA）：事实和假设

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Dehydroepiandrosterone (DHEA) is considered as an important immunomodulating and anti-inflammatory hormone. Despite the continuing interest in DHEA replacement therapy, our knowledge of its effects upon asthma is very limited. DHEA is able to reverse cytokine imbalances associated with asthma, may prevent and attenuate allergic inflammation in airways, and does not possess the undesirable side effects of glucocorticoids; therefore, it may be potentially applied in the treatment of asthma. The steroid-sparing effect observed with DHEA clinically could appear especially favorable in asthmatic patients receiving oral treatment and those inhaling high doses of glucocorticoids. In addition, DHEA and its analogs might prove useful in reversing relative glucocorticoids insensitivity in patients with corticosteroid-resistant asthma. In this review we have focused specifically on DHEA’s role in asthma.

机译：脱氢表雄酮（DHEA）被认为是重要的免疫调节和消炎激素。尽管人们一直对DHEA替代疗法产生兴趣，但是我们对它对哮喘的影响的了解非常有限。 DHEA能够逆转与哮喘相关的细胞因子失衡，可以预防和减轻气道过敏性炎症，并且不具有糖皮质激素的不良副作用；因此，它可能潜在地用于哮喘的治疗。在接受口服治疗的哮喘患者和吸入大剂量糖皮质激素的哮喘患者中，用DHEA观察到的在临床上观察到的降低类固醇的效果可能特别有利。此外，DHEA及其类似物可能被证明可用于逆转糖皮质激素抵抗性哮喘患者的相对糖皮质激素敏感性。在这篇评论中，我们特别关注了脱氢表雄酮在哮喘中的作用。

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《Inflammation》 |2010年第5期|p.320-324|共5页
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Alicja Kasperska-Zajac;
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1. Asthma and dehydroepiandrosterone (DHEA): facts and hypotheses. [J] . Kasperska Zajac A Inflammation . 2010,第5期

机译：哮喘和脱氢表雄酮（DHEA）：事实和假设。
2. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach [J] . do Vale Sonia, Selinger Lenka, Martins Joao Martin, Hormones and behavior . 2015,第Null期

机译：脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）和情绪加工-行为和电生理方法
3. Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients. [J] . Aldred S, Mecocci P Archives of Gerontology and Geriatrics: An International Journal Integrating Experimental, Clinical and Social Studies on Ageing . 2010,第1期

机译：阿尔茨海默氏病（AD）患者血浆中的脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）浓度降低。
4. Mitochondrial DNA copy number and citrate synthase activity in nonalcoholic fatty liver disease induced in rats by a high-fat plus fructose diet fortified or not with dehydroepiandrosterone (DHEA) [C] . ANGELA MARIA LEZZA, PIERLUIGI CASSANO, RAFFAELLA MASTROCOLA, WSEAS International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2009

机译：在大鼠诱导的高醇脂肪肝病中，用高脂肪加果糖饮食强化或不含脱氢食品（DHEA）的线粒体DNA拷贝数和柠檬酸合酶活性
5. Dehydroepiandrosterone (DHEA) metabolism and its role in preadipocyte growth and differentiation. [D] . Lea-Currie, Yolanda Renee. 1999

机译：脱氢表雄酮（DHEA）代谢及其在前脂肪细胞生长和分化中的作用。
6. Determination of functional states during sepsis-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis using measurement of ACTH cortisol dehydroepiandrosterone-sulfate (DHEAS) and dehydroepiandrosterone (DHEA) [O] . C Marx, M Wendt, S Petros, 2003

机译：脓毒症诱导的下丘脑-垂体-肾上腺（HPA）轴激活过程中的功能状态测定方法是测量ACTH皮质醇硫酸脱氢表雄酮（DHEAS）和脱氢表雄酮（DHEA）
7. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing — A behavioral and electrophysiological approach [O] . do Vale Sónia, Selinger Lenka, Martins João Martin, 2015

机译：脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）和情绪加工—行为和电生理方法

Asthma and Dehydroepiandrosterone (DHEA): Facts and Hypotheses

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