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首页> 外文期刊>Inflammation >Involvement of Heme Oxygenase-1 in Kaempferol-Induced Anti-Allergic Actions in RBL-2H3 Cells
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Involvement of Heme Oxygenase-1 in Kaempferol-Induced Anti-Allergic Actions in RBL-2H3 Cells

机译：血红素加氧酶-1参与山emp酚诱导的RBL-2H3细胞的抗过敏作用。

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Kaempferol is one of the most commonly found dietary flavonoids. The exposure to kaempferol is known to inhibit degranulation from mast cells, but the inhibitory mechanism of degranulation has not been clarified yet. In this study, we investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of kaempferol against degranulation in rat basophilic leukemia (RBL-2H3) cells. Our results demonstrate upregulation of HO enzymatic activity after short (15 min) exposure to kaempferol, followed by the induction of HO-1 expression in protein. The involvement of HO-1 in the kaempferol-induced inhibition of degranulation was confirmed using tin protoporphyrin IX (SnPP), a HO-1 inhibitor. These findings strongly suggest that kaempferol exerts anti-allergic actions via activation of the HO-1.
机译：山emp酚是最常见的饮食类黄酮之一。已知暴露于山ka酚可抑制肥大细胞脱颗粒，但尚未阐明脱颗粒的抑制机制。在这项研究中，我们调查了血红素加氧酶（HO）-1参与山fer酚对大鼠嗜碱性粒细胞白血病（RBL-2H3）细胞脱颗粒的抗过敏作用。我们的结果证明短时间（15分钟）暴露于山奈酚后HO酶活性上调，然后诱导HO-1在蛋白质中的表达。使用HO-1抑制剂锡原卟啉IX（SnPP）证实了HO-1参与了山萘酚诱导的脱粒抑制。这些发现强烈表明山ka酚通过HO-1的活化发挥抗过敏作用。

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