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首页> 外文期刊>Inflammation >IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population
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IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population

机译：口腔扁平苔藓患者唾液中的IFN-γ和IL-4：在华人人群中的研究

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摘要

Interferon-gamma (IFN-γ) and interleukin-4 (IL-4) represent T helper 1 (Th1) and T helper 2 (Th2) cytokines involved in oral lichen planus (OLP), respectively. This study was to investigate the expression profile of IFN-γ and IL-4 in saliva of OLP patients. Seventy-nine ethnic Chinese patients with OLP were recruited for this study, together with 41 age–sex-matched healthy volunteers served as control group. IFN-γ and IL-4 levels in whole unstimulated saliva were screened by enzyme linked immunosorbent assay. OLP patient showed a low-level IFN-γ but high-level IL-4 expression profile in saliva, with a lower ratio of salivary IFN-γ/IL-4 compared to healthy controls. With regards to subtypes, salivary IL-4 level in erythematous/ulcerative group was significantly higher than that in reticular group. Imbalance of Th1/Th2 cytokines with Th2-predominant profile in saliva may be involved in OLP. Salivary IL-4 level may be a fine biomarker reflecting the severity of OLP.
机译：γ-干扰素（IFN-γ）和白介素4（IL-4）分别代表口腔扁平苔藓（OLP）涉及的T辅助细胞1（Th1）和T辅助细胞2（Th2）。本研究旨在探讨IFN-γ和IL-4在OLP患者唾液中的表达情况。本研究共招募了79名华裔OLP患者，并以41名年龄性别匹配的健康志愿者作为对照组。通过酶联免疫吸附试验筛选整个未刺激唾液中的IFN-γ和IL-4水平。 OLP患者在唾液中显示低水平的IFN-γ但高水平的IL-4表达谱，与健康对照组相比，唾液中IFN-γ/ IL-4的比例较低。就亚型而言，红斑/溃疡性组的唾液IL-4水平显着高于网状组。唾液中以Th2为主的Th1 / Th2细胞因子失衡可能与OLP有关。唾液IL-4水平可能是反映OLP严重程度的良好生物标志物。

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