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首页> 外文期刊>Inflammation >Effect of Salvia miltiorrhizae on Pulmonary Apoptosis of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
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Effect of Salvia miltiorrhizae on Pulmonary Apoptosis of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

机译：丹参对重症急性胰腺炎或梗阻性黄疸大鼠肺细胞凋亡的影响

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摘要

To investigate the effect of apoptosis about Salvia miltiorrhizae injection on the lungs of SAP and OJ rats. Total 288 rats were used for SAP-associated experiments and OJ-associated experiments, respectively. The rats were randomly divided into sham-operated, model control and treated group. According to the difference of time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The pathological changes, expression levels of Bax protein and apoptotic indexes in the lungs of SAP or OJ rats were observed, and the mortality rates of SAP or OJ rats were recorded, respectively. The numbers of dead SAP and OJ rats in treated groups declined. The pathological changes in the lungs of SAP or OJ rats in treated groups were relieved to varying degrees. There was no marked difference in pathological severity scores and the positive staining intensity of Bax protein between treated groups and model control groups (all P > 0.05). Salvia miltiorrhizae has some protective effect on the lungs of rats with SAP or OJ which may be related apoptosis although our results can not find significant difference between treated groups and model control groups.
机译：探讨丹参注射液对SAP和OJ大鼠肺组织凋亡的影响。总共288只大鼠分别用于SAP相关实验和OJ相关实验。将大鼠随机分为假手术组，模型对照组和治疗组。根据手术后时间点的差异，将每组SAP大鼠分为3、6、12 h组，将OJ大鼠分为7、14、21和28d组。观察SAP或OJ大鼠肺的病理变化，Bax蛋白的表达水平和细胞凋亡指数，并记录SAP或OJ大鼠的死亡率。治疗组中死亡的SAP和OJ大鼠的数量下降。治疗组SAP或OJ大鼠肺部的病理变化均有不同程度的缓解。治疗组和模型对照组之间的病理严重程度评分和Bax蛋白阳性染色强度均无显着差异（均P> 0.05）。丹参对SAP或OJ大鼠的肺有一定的保护作用，可能与细胞凋亡有关，尽管我们的结果在治疗组和模型对照组之间没有发现显着差异。

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