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首页> 外文期刊>International journal of business and systems research >Research on drug-induced liver injury in association with co-infections and anti-tuberculosis drugs
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Research on drug-induced liver injury in association with co-infections and anti-tuberculosis drugs

机译：与合并感染和抗结核药物相关的药物性肝损伤的研究

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This study uses data mining techniques to find out the risk factors for the tuberculosis (TB) patients with drug-induced liver injury (DILI). The Taiwan National Health Insurance Database is used for collection of domestic TB cases during 2004-2011 to study these TB patients and their drug prescribing patterns in order to build a model to predict the risk of drug-drug interaction between hepatitis B and C, acquired immune deficiency syndrome (AIDS) and TB. The results out of the total 188,032 TB patients have shown that 77,574 have taken anti-TB drugs. Afterwards, DILI occurred in 0.7% of the cases. Besides, for those DILI patients associated with TB and hepatitis B or C, this study reveals that DILI is associated with the use of ethambutol and rifampin. It is suggested that TB patients associated with hepatitis C should pay attention to their uses of rifampicin, and TB patients (especially males) associated with hepatitis B should pay attention to the ethambutol's impact on DILI. Moreover, our results also showed that having both AIDS and TB shows no significant effect on DILI.
机译：这项研究使用数据挖掘技术来找出患有药物性肝损伤（DILI）的结核病（TB）患者的危险因素。台湾国家健康保险数据库用于收集2004-2011年期间的国内结核病病例，以研究这些结核病患者及其药物处方模式，从而建立模型来预测获得的乙型肝炎和丙型肝炎之间药物与药物相互作用的风险免疫缺陷综合症（艾滋病）和结核病。总共188,032 TB患者中的结果表明，有77,574例服用了抗结核药物。之后，发生DILI的案例占0.7％。此外，对于那些与结核病和乙型或丙型肝炎相关的DILI患者，这项研究表明，DILI与乙胺丁醇和利福平的使用有关。建议与丙型肝炎有关的结核病患者应注意使用利福平，而与乙型肝炎有关的结核病患者（尤其是男性）应注意乙胺丁醇对DILI的影响。此外，我们的研究结果还表明，同时患有艾滋病和结核病对DILI没有显着影响。

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