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首页> 外文期刊>The International Journal of Cardiovascular Imaging >Global and regional wall motion abnormalities of pacing-induced heart failure assessed by multi-detector row CT: a patient and canine model study
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Global and regional wall motion abnormalities of pacing-induced heart failure assessed by multi-detector row CT: a patient and canine model study

机译：多探测器行CT评估起搏诱发的心力衰竭的整体和区域壁运动异常：病人和犬模型研究

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摘要

This study used multi-detector row CT (MDCT) to evaluate the regional geometric parameters of left ventricle (LV) in patients and dogs after right ventricular apical (RVA) pacing. First, we measured and compared the global and regional wall motion parameters derived from MDCT images between three patients post RVA pacing and seven age-matched healthy subjects. The LV ejection fraction (LVEF), LV end-diastolic volume and LV end-systolic volume were measured. We also measured the regional wall thickness, wall thickening and regional wall motion in 12 different segments of the LV. Second, we performed MDCT scan on five dogs as the study group (pacing wire + RVA pacing, 2 months) and four dogs as the sham control group (pacing wire, 2 months). The global and regional geometric parameters were compared within both human and canine groups. Compared with normal subjects, patients post RVA pacing had low LVEF (60.4 ± 10.5 vs. 33.2 ± 17.6, P = 0.014), impaired regional wall thickening and regional wall motion, particularly in segments near the pacing lead. Some segments near the pacing lead were showing dyskinesia after pacing. These findings were successfully reproduced in the canine model. We found that RVA pacing can result in impaired regional wall thickening and regional wall motion, particularly in segments near the pacing lead.
机译：这项研究使用多排行CT（MDCT）来评估患者和狗在右心室顶端（RVA）起搏后左心室（LV）的区域几何参数。首先，我们测量并比较了三名RVA起搏后的患者和七名年龄匹配的健康受试者从MDCT图像得出的整体和区域壁运动参数。测量左室射血分数（LVEF），左室舒张末期容积和左室收缩末期容积。我们还测量了LV的12个不​​同部分的区域壁厚，壁增厚和区域壁运动。其次，我们对五只狗作为研究组（起搏线+ RVA起搏，2个月）和四只狗作为假对照组（起搏线，2个月）进行了MDCT扫描。在人类和犬类中比较了全局和区域几何参数。与正常受试者相比，RVA起搏后患者的LVEF低（60.4±10.5 vs. 33.2±17.6，P = 0.014），区域壁增厚和区域壁运动受损，尤其是在起搏导线附近的区域。起搏导线附近的某些节段起搏后显示运动障碍。这些发现已在犬模型中成功复制。我们发现RVA起搏会导致区域壁增厚和区域壁运动受损，特别是在起搏导线附近的节段中。

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    I-Chen Tsai; Jin-Long Huang; Kwo-Chang Ueng; Yi-Wen Hung; Chin-Fang Hung; Wan-Chun Liao; Ho-Yi Lei; Min-Chi Chen; Wei-Lin Tsai; Shih-Ann Chen; Clayton Chi-Chang Chen; Yun-Ching Fu; Chih-Tai Ting;

  • 作者单位

    Department of Radiology Taichung Veterans General Hospital Taichung Taiwan;

    Faculty of Medicine and Institute of Clinical Medicine National Yang Ming University Taipei Taiwan;

    Division of Cardiology and Cardiovascular Research Group Institute of Medicine Chung-Shan Medical University Hospital Taichung Taiwan;

    Department of Education and Research Taichung Veterans General Hopsital Taichung Taiwan;

    Cardiovascular Center Taichung Veterans General Hospital No. 160 Sec. 3 Taichung Harbor Road 407 Taichung Taiwan;

    Department of Radiology Taichung Veterans General Hospital Taichung Taiwan;

    Cardiovascular Center Taichung Veterans General Hospital No. 160 Sec. 3 Taichung Harbor Road 407 Taichung Taiwan;

    Department of Radiology Taichung Veterans General Hospital Taichung Taiwan;

    Department of Radiology Taichung Veterans General Hospital Taichung Taiwan;

    Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan;

    Department of Radiology Taichung Veterans General Hospital Taichung Taiwan;

    Faculty of Medicine and Institute of Clinical Medicine National Yang Ming University Taipei Taiwan;

    Faculty of Medicine and Institute of Clinical Medicine National Yang Ming University Taipei Taiwan;

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  • 正文语种 eng
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  • 关键词

    Multi-detector row computed tomography; Computed tomography; Pacemaker; Regional wall motion; Heart failure; Pacing;

    机译：多探测器行计算机体层摄影术;计算机断层摄影术;起搏器;区域壁运动;心力衰竭;起搏;

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