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HEMODYNAMICS OF A CEREBRAL ANEURYSM UNDER REST AND EXERCISE CONDITIONS

机译：休息和运动条件下脑动脉的血流动力学

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Physiological flow under rest and exercise conditions in patient-specific cerebral aneurysm models is numerically investigated. A finite-volume based code with BiCGStab as the linear equation solver is used to simulate unsteady three-dimensional flow field through the incompressible Navier-Stokes equations. Flow characteristics are first established in a healthy cerebral artery for both physiological conditions. The effect of saccular aneurysm on cerebral hemodynamics is then explored through a comparative analysis of the velocity distribution, nature of flow patterns, wall pressure and wall shear stress (WSS) against the reference configuration. The efficacy of coil embolization as a potential strategy of surgical intervention is also examined by modelling coil as a homogeneous and isotropic porous medium where the extended Darcy's law, including Forchheimer and Brinkman terms, is applicable. The Carreau-Yasuda non-Newtonian blood model is incorporated to capture the shear thinning behavior of blood. Rest and exercise conditions correspond to normotensive and hypertensive blood pressures respectively. The results indicate that the fluid impingement on the outer wall of the arterial bend leads to abnormality in the distribution of wall pressure and WSS, which is expected to be the primary cause of the localized aneurysm. Exercise correlates with elevated flow velocity, vortex strength, wall pressure and WSS inside the aneurysm sac. With the insertion of coils in the aneurysm cavity, the flow bypasses the dilatation, leading to a decline in flow velocities and WSS. Lower particle residence time under exercise conditions arrests atherosclerosis.
机译：数值研究了患者特定的脑动脉瘤模型在休息和运动条件下的生理流动。使用BiCGStab作为线性方程求解器的基于有限体积的代码，通过不可压缩的Navier-Stokes方程来模拟不稳定的三维流场。首先针对两种生理条件在健康的脑动脉中建立血流特性。然后，通过对比参考配置对速度分布，流型性质，壁压力和壁切应力（WSS）进行比较分析，探索了囊状动脉瘤对脑血流动力学的影响。通过将线圈建模为均匀且各向同性的多孔介质，在适用扩展的达西定律（包括Forchheimer和Brinkman术语）的情况下，也可以检验线圈栓塞作为一种潜在的外科手术策略的功效。合并了Carreau-Yasuda非牛顿血液模型以捕获血液的剪切稀化行为。休息和运动条件分别对应于血压正常和高血压。结果表明，流体撞击动脉弯曲的外壁会导致壁压力和WSS的分布异常，这可能是局部动脉瘤的主要原因。运动与动脉瘤囊内部流速，涡流强度，壁压和WSS升高有关。随着在动脉瘤腔中插入线圈，血流绕过扩张，导致血流速度和WSS下降。运动条件下较低的颗粒停留时间可阻止动脉粥样硬化。

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