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首页> 外文期刊>Clean air >HEMODYNAMICS OF A CEREBRAL ANEURYSM UNDER REST AND EXERCISE CONDITIONS
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HEMODYNAMICS OF A CEREBRAL ANEURYSM UNDER REST AND EXERCISE CONDITIONS

机译：休息和运动条件下脑动脉瘤的血流动力学

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摘要

Physiological flow under rest and exercise conditions in patient-specific cerebral aneurysm models is numerically investigated. A finite-volume based code with BiCGStab as the linear equation solver is used to simulate unsteady three-dimensional flow field through the incompressible Navier-Stokes equations. Flow characteristics are first established in a healthy cerebral artery for both physiological conditions. The effect of saccular aneurysm on cerebral hemodynamics is then explored through a comparative analysis of the velocity distribution, nature of flow patterns, wall pressure and wall shear stress (WSS) against the reference configuration. The efficacy of coil embolization as a potential strategy of surgical intervention is also examined by modelling coil as a homogeneous and isotropic porous medium where the extended Darcy's law, including Forchheimer and Brinkman terms, is applicable. The Carreau-Yasuda non-Newtonian blood model is incorporated to capture the shear thinning behavior of blood. Rest and exercise conditions correspond to normotensive and hypertensive blood pressures respectively. The results indicate that the fluid impingement on the outer wall of the arterial bend leads to abnormality in the distribution of wall pressure and WSS, which is expected to be the primary cause of the localized aneurysm. Exercise correlates with elevated flow velocity, vortex strength, wall pressure and WSS inside the aneurysm sac. With the insertion of coils in the aneurysm cavity, the flow bypasses the dilatation, leading to a decline in flow velocities and WSS. Lower particle residence time under exercise conditions arrests atherosclerosis.
机译：在数值上研究了静止患者特异性脑动脉瘤模型中的生理流动和运动条件。具有BICGSTAB的有限卷的代码，因为线性方程求解器用于通过不可压缩的Navier-Stokes方程来模拟不稳定的三维流场。流动特性首先在健康的脑动脉中建立，用于生理条件。然后通过对参考配置的速度分布，流动模式，壁压和壁剪切应力（WSS）的比较分析来探索囊状动脉瘤对脑血流动力学的影响。还通过将线圈作为均匀和各向同性多孔介质建模，作为均匀和各向同性多孔介质的均匀和各向同性多孔介质来检查线圈栓塞作为潜在策略的疗效是适用的。 Carreau-Yasuda非牛顿血液模型被纳入捕获血液的剪切变薄行为。休息和运动条件分别对应于正常和高血压血压。结果表明，动脉弯曲的外壁上的流体冲击导致壁压和WSS分布的异常，这预期是局部动脉瘤的主要原因。运动与动脉瘤囊内的升高的流速，涡流强度，壁压和有线电布相关。随着在动脉瘤腔内的线圈插入，流量绕过膨胀，导致流速下降速度和WSS。运动条件下的粒子停留时间抑制动脉粥样硬化。

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