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Temperature distribution in multi-layer skin tissue in presence of a tumor

机译:肿瘤存在下多层皮肤组织中的温度分布

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Analytical investigation of bioheat transfer is of significant importance for numerous medical applications, for example in thermally-driven treatments for cancer. While bioheat transfer has been investigated for a number of specific conditions, relatively less work exists on bioheat transfer in a multilayer structure, such as skin. This paper presents an analytical solution for the steady-state Pennes bioheat equation in a multi-layer structure. The temperature distribution in each layer is derived separately and interface temperature and heat flux compatibility conditions are used to determine the complete solution. This solution is used to analyze the effect of heat generation during thermal therapy on a tumor in skin, which is modeled as a five-layer structure. The model is capable of accounting for the effects of various therapeutic measures such as cryotherapy, laser treatment, etc. as well as various physical phenomena such as conduction, blood perfusion and metabolism. The model is used to analyze the effect of various physical parameters on the temperature distribution. This theoretical treatment, as well as the quantitative results presented here may help improve the fundamental understanding of bioheat transfer in a layered structure such as skin.
机译:生物热传递的分析研究对于许多医学应用(例如在癌症的热驱动疗法中)具有重要意义。尽管已经针对许多特定条件研究了生物热传递,但是在诸如皮肤的多层结构中进行生物热传递的工作相对较少。本文提出了多层结构中稳态Pennes生物热方程的解析解。分别得出每个层中的温度分布,并使用界面温度和热通量相容性条件确定完整的解决方案。该解决方案用于分析热疗法对皮肤肿瘤的热效应,该效应被建模为五层结构。该模型能够说明各种治疗措施(例如冷冻疗法,激光治疗等)以及各种物理现象(例如传导,血液灌注和新陈代谢)的影响。该模型用于分析各种物理参数对温度分布的影响。这种理论处理以及此处给出的定量结果可能有助于提高对诸如皮肤之类的分层结构中生物热传递的基本理解。

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