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首页> 外文期刊>International Journal of Heat and Mass Transfer >Numerical and experimental investigation on flow and mixing in batch-mode centrifugal microfluidics
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Numerical and experimental investigation on flow and mixing in batch-mode centrifugal microfluidics

机译：间歇式离心微流体流动与混合的数值与实验研究

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The vortical flow leading to mixing in micro-chamber due to Euler/inertial force from continuous cyclic acceleration-and-deceleration under unidirectional rotation has been investigated both numerically and experimentally. The primary vortex as seen from numerical model during acceleration was confirmed by flow visualization by monitoring the motion of the interface between two miscible dyed liquids, and by tracking the movement of neutrally buoyant particles in the flow. In a typical test, a total of 15 cycles (equivalent to 150 s) was required to achieve uniform mixing by continuously angular acceleration-and-deceleration. This is much shorter when compared to mixing of liquids by molecular diffusion for the same test geometry (stationary) which took at least 2400 s to reach uniform mixture. For practical application, the effectiveness of mixing is quantified by a specific mixing time (SMT), which corresponds to the time for mixing quality, a, to reach 90% normalized by the volume of the mixture in the chamber. Lower SMT is indicative of more effective mixing. SMT was found to decrease with increasing (a) outer radius, (b) angular span, and (c) acceleration/deceleration as a result of stronger vortical flow. For small angular span (i.e. 5°) wherein mixing is slow, increasing acceleration from 17 to 34 rad/s2 can compensate mixing, whereas for larger angular span (i.e. 20°) this is not as significant as mixing is already quite effective. Experimental measurements on SMT agree well with those of the numerical model.
机译：通过数值和实验研究了由于单向旋转下连续的周期性加减速产生的欧拉/惯性力导致微腔内混合的涡流。在流动过程中，通过监视两种可混染液体之间的界面运动并跟踪流中的中性浮力颗粒的运动，可以通过流动可视化确定从数值模型中看到的主旋涡。在典型的测试中，总共需要15个循环（相当于150 s），以通过连续的角度加减速实现均匀混合。与在相同的测试几何形状（静态）下通过分子扩散混合液体（至少需要2400 s才能达到均匀混合）相比，这要短得多。对于实际应用，混合的有效性通过特定的混合时间（SMT）来量化，该时间对应于混合质量a达到达到90％的时间，该时间由室内的混合物体积归一化。较低的SMT表示更有效的混合。由于较强的涡流，SMT随着（a）外半径，（b）角跨度和（c）加速/减速的增加而减小。对于混合慢的小角度跨度（即5°），将加速度从17 rad / s2增加到34 rad / s2可以补偿混合，而对于较大的角度跨度（即20°），这并不像混合已经很有效那样重要。 SMT上的实验测量与数值模型非常吻合。

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