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首页> 外文期刊>International Journal of Legal Medicine >Frequency of different anti-depressants associated with suicides and drug deaths
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Frequency of different anti-depressants associated with suicides and drug deaths

机译：与自杀和药物死亡相关的不同抗抑郁药的发生频率

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From each case of suicide and drug-related death autopsied in the Institute of Forensic Medicine, Munich during the years 2001–2005, a toxicological investigation on anti-depressants (AD) was performed. In 180 suicides and 72 narcotic drug death cases, ADs were detected: 4 different classic tricyclic anti-depressants (TCAs), 6 other non-selective monoamine re-uptake inhibitors (NSMRIs), 5 selective serotonin re-uptake inhibitors (SSRIs) and 3 other ADs. The suicides were grouped further according to the type of suicide (violent or non-violent). The prescription frequency of the ADs in Germany, expressed as the defined daily dosages (DDDs), during the investigated years served for comparison. There were serious differences in the frequency of different ADs regarding to the manner of suicide. In cases associated with doxepin and trimipramine, non-violent suicides were distinctly over-represented, as in cases in which the drug itself was responsible for the death as in cases of non-violent suicides in other manners. In contrast, in cases with citalopram or opipramol, violent forms of suicides were significantly over-represented. For amitriptyline, the ratio was approximately balanced. For the remainder of the ADs, the case numbers were too low for a valid evaluation. The different frequency distributions of the ADs, associated with violent and non-violent suicides may be explained by their different pharmacological active profiles and the different lethality of overdoses of the different ADs. There was no indication at all for a special suicidal problem of SSRIs in juveniles. Amongst 1,127 suicides within 5 years, in an area with approximately 5 million people, the youngest suicide victim with SSRIs was 28 years old. In drug death cases, citalopram was obviously over-represented.
机译：从2001年至2005年在慕尼黑法医研究所对每例自杀和与药物相关的死亡进行尸检，对抗抑郁药（AD）进行了毒理学调查。在180例自杀和72例麻醉药死亡案例中，发现了AD：4种不同的经典三环抗抑郁药（TCA），6种其他非选择性单胺再摄取抑制剂（NSMRIs），5种选择性5-羟色胺再摄取抑制剂（SSRI）和其他3个广告。根据自杀类型（暴力或非暴力）将自杀进一步分组。在调查的年份中，德国的AD处方频率以定义的每日剂量（DDD）表示，用于比较。关于自杀方式，不同AD的频率存在严重差异。在与多塞平和曲米帕明有关的病例中，非暴力自杀的人数明显过高，例如在毒品本身以其他方式导致死亡的情况下，自杀本身就是如此。相比之下，在服用西酞普兰或奥普拉莫的情况下，以暴力形式自杀的人数明显过多。对于阿米替林，该比例大致平衡。对于其余的AD，案件数量太低，无法进行有效评估。与暴力和非暴力自杀有关的AD的不同频率分布可以通过其不同的药理活性图谱和不同AD过量的致死率来解释。完全没有迹象表明青少年有特别的SSRI自杀问题。在5年内的1,127例自杀中，该地区约有500万人，最年轻的SSRI自杀受害者是28岁。在毒品死亡案件中，西酞普兰的人数明显过多。

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