1,2,3-Triazole Fused Quinoline-Peptidomimetics: Studies on Synthesis, DNA Binding and Photonuclease Activity

T. Aravinda; H. S. Bhojya Naik; H. R. Prakash Naik

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1,2,3-Triazole Fused Quinoline-Peptidomimetics: Studies on Synthesis, DNA Binding and Photonuclease Activity

机译：1,2,3-三唑融合喹啉拟肽：合成，DNA结合和光核酸酶活性的研究

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We present, simple approach for the accession of 1,2,3-triazole fused quinoline peptide analogues from 3-(azidomethyl)-2-chloroquinoline in a three-step mechanistic pathway. The UV–Visible absorbance plot shows dynamic interaction of parent triazole derivative with CT DNA as efficient DNA intercalator (K b = 4.6 × 10?4 M?1). Finally, the efficient DNA damage was observed on photo-irradiation at 360 nm in the presence of 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionic acid 1-(2-chloro-quinolin-3-ylmethyl)-1H-[1,2,3]triazole-4-ylmethyl ester (6a).

机译：我们提出了一种简单的方法，可通过三步机制途径从3-（叠氮甲基）-2-氯喹啉中加入1,2,3-三唑稠合喹啉肽类似物。紫外可见吸收图显示了母体三唑衍生物与CT DNA作为有效的DNA嵌入剂（K b = 4.6×10？4 M？1 ）的动态相互作用。最后，在2-（9H-氟-9-基甲氧基羰基氨基）-丙酸1-（2-氯喹啉-3-基甲基）-1H-[[]存在下于360 nm光照射下观察到有效的DNA损伤。 1,2,3]三唑-4-基甲基酯（6a）。

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《International Journal of Peptide Research and Therapeutics》 |2009年第4期|273-279|共7页
作者
T. Aravinda; H. S. Bhojya Naik; H. R. Prakash Naik;
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作者单位

Department of Studies and Research in Industrial Chemistry School of Chemical Sciences Kuvempu University Shankaraghatta Karnataka 577 451 India;

Department of Studies and Research in Industrial Chemistry School of Chemical Sciences Kuvempu University Shankaraghatta Karnataka 577 451 India;

Department of Studies and Research in Industrial Chemistry School of Chemical Sciences Kuvempu University Shankaraghatta Karnataka 577 451 India;

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正文语种 eng
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1,2,3-triazole-quinoline; Peptidomimetics; DNA binding-photocleavage;

机译：1,2,3-三唑喹啉;拟肽;DNA结合-光裂解;

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1. 1,2,3-Triazole Fused Quinoline-Peptidomimetics: Studies on Synthesis, DNA Binding and Photonuclease Activity [J] . T. Aravinda, H. S. Bhojya Naik, H. R. Prakash Naik International journal of peptide research and therapeutics . 2009,第4期

机译：1,2,3-三唑融合喹啉拟肽：合成，DNA结合和光核酸酶活性的研究
2. Iminosugars Spiro-Linked with Morpholine-Fused 1,2,3-Triazole: Synthesis, Conformational Analysis, Glycosidase Inhibitory Activity, Antifungal Assay, and Docking Studies [J] . Shrawan R. Chavan, Kishor S. Gavale, Ayesha Khan, ACS Omega . 2017,第10期

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3. Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity. [J] . Kamal A, Shankaraiah N, Devaiah V, Bioorganic and Medicinal Chemistry Letters . 2008,第4期

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4. Synthesis and characterization of 1-amino-4-nitro-1,2,3-triazole and 2-amino-4-nitro-1,2,3-triazole [C] . Dominique R. Wozniak, Benjamin Salfer, Matthias Zeller, . 2020

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5. Synthesis of Functional 1,2,3-Triazoles and Its Applications in Transition Metal Catalysis. [D] . Yan, Wuming. 2012

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6. Iminosugars Spiro-Linked withMorpholine-Fused 123-Triazole:Synthesis Conformational Analysis Glycosidase Inhibitory ActivityAntifungal Assay and Docking Studies [O] . ShrawanR. Chavan, Kishor S. Gavale, Ayesha Khan, 2017

机译：氨基糖螺旋连接吗啉融合的123-三唑：合成构象分析糖苷酶抑制活性抗真菌分析和对接研究
7. Iminosugars Spiro-Linked with Morpholine-Fused 1,2,3-Triazole: Synthesis, Conformational Analysis, Glycosidase Inhibitory Activity, Antifungal Assay, and Docking Studies [O] . Shrawan R. Chavan, Kishor S. Gavale, Ayesha Khan, 2017

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8. Synthesis, Characterization, and Structural Investigations of 1-amino-3-Substituted- 1,2,3-Triazolium Salts, and a New Route to 1-substituted-1,2,3- triazoles [R] . Kaplan, G. , Drake, G. , Tollison, K. , 2004

机译：1-氨基-3-取代-1,2,3-三唑盐的合成，表征和结构研究，以及1-取代-1,2,3-三唑的新途径

1,2,3-Triazole Fused Quinoline-Peptidomimetics: Studies on Synthesis, DNA Binding and Photonuclease Activity

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