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首页> 外文期刊>International journal of terraspace science and engineering >Mesomechanics challenges in mammalian tissue cell kinetics research at micro- and nano-length scales
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Mesomechanics challenges in mammalian tissue cell kinetics research at micro- and nano-length scales

机译：微观和纳米尺度的哺乳动物组织细胞动力学研究中的细观力学挑战

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摘要

With the development of techniques for routine culture of mammalian tissue cells, regard for mesomechanics ideas in tissue cell biology became largely agnostic. In particular, recognition of universal tissue cell streaming driven by the asymmetric self-renewal of tissue stem cells is now rarely considered in major schools of thought in cell biology. Given this history, the current challenges to tissue cell mesomechanics research include restoring a general appreciation of dynamic mammalian tissue cell kinetics as a fundamental principle of tissue cell biology. Recovery of this lost concept will require attractive new advances in knowledge of the factors and forces that are integrated over several orders of magnitudes of length scale and time scale to achieve normal tissue function. Advances in tissue engineering, live in situ cell imaging, and tissue cell-specific biomarker discovery are predicted to be essential developments for meeting these challenges in tissue mesomechanics research.
机译：随着哺乳动物组织细胞常规培养技术的发展，在组织细胞生物学中考虑细观力学的想法已变得不可知。特别地，在细胞生物学的主要思想流派中，如今很少考虑由组织干细胞的不对称自我更新驱动的对通用组织细胞流的识别。考虑到这一历史，组织细胞细观力学研究的当前挑战包括恢复对动态哺乳动物组织细胞动力学的普遍认识，并将其作为组织细胞生物学的基本原理。要恢复这种迷失的观念，将需要在因素和作用力方面取得令人瞩目的新进展，这些因素和作用力需要在几个数量级的长度范围和时间范围内整合以实现正常组织功能。预测组织工程，原位活细胞成像和组织细胞特异性生物标志物发现方面的进展将是应对组织细观力学研究中这些挑战的必不可少的发展。

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