DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification

Jennifer E L Templeton; Paul M Brotherton; Bastien Llamas; Julien Soubrier; Wolfgang Haak; Alan Cooper; Jeremy J Austin

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DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification

机译：DNA捕获和下一代测序可从高度降解的样品中恢复整个线粒体基因组，以供人类识别

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Background Mitochondrial DNA (mtDNA) typing can be a useful aid for identifying people from compromised samples when nuclear DNA is too damaged, degraded or below detection thresholds for routine short tandem repeat (STR)-based analysis. Standard mtDNA typing, focused on PCR amplicon sequencing of the control region (HVS I and HVS II), is limited by the resolving power of this short sequence, which misses up to 70% of the variation present in the mtDNA genome.

机译：背景技术线粒体DNA（mtDNA）分型可在核DNA过于受损，降解或低于基于常规短串联重复序列（STR）的检测阈值时从受损样品中鉴定人。专注于控制区（HVS I和HVS II）的PCR扩增子测序的标准mtDNA分型受到该短序列分辨力的限制，该短序列错过了mtDNA基因组中70％的变异。

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《Investigative Genetics》 |2013年第1期|1-13|共13页
作者
Jennifer E L Templeton; Paul M Brotherton; Bastien Llamas; Julien Soubrier; Wolfgang Haak; Alan Cooper; Jeremy J Austin;
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正文语种 eng
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关键词
Mitochondrial DNA; Degraded DNA; Ancient DNA; DNA hybridisation; DNA enrichment; Forensic science; Next-generation sequencing;

机译：线粒体DNA;降解的DNA;古代DNA DNA杂交;DNA富集;法医科学;下一代测序;

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1. DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification [J] . Jennifer E L Templeton, Paul M Brotherton, Bastien Llamas, Investigative Genetics . 2013,第1期

机译：DNA捕获和下一代测序可从高度降解的样品中恢复整个线粒体基因组，以供人类识别
2. Efficient cross-species capture hybridization and next-generation sequencing of mitochondrial genomes from noninvasively sampled museum specimens. [J] . Mason VC, Li G, Helgen KM, Genome research . 2011,第10期

机译：高效的跨物种捕获非侵入性采样博物馆标本的线粒体基因组杂交和下一代测序。
3. Direct next-generation sequencing of virus-human mixed samples without pretreatment is favorable to recover virus genome [J] . Dingchen Li, Zongwei Li, Zhe Zhou, Biology Direct . 2016,第1期

机译：无需预处理即可直接对病毒-人混合样品进行下一代测序，有利于恢复病毒基因组
4. A novel approach for genotyping of LCN-DNA recovered from highly degraded samples [C] . C. Romano, E. Di Luise, D. Di Martino, International Society for Forensic Genetics . 2006

机译：高层样品中回收LCN-DNA的基因分型新方法
5. Preparing whole genome human mitochondrial DNA libraries for next generation sequencing using Illumina Nextera XT. [D] . Stawski, Hilde. 2013

机译：准备全基因组人类线粒体DNA文库，以使用Illumina Nextera XT进行下一代测序。
6. DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification [O] . Jennifer E L Templeton, Paul M Brotherton, Bastien Llamas, 2013

机译：DNA捕获和下一代测序可从高度降解的样品中恢复整个线粒体基因组以供人类识别
7. DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification [O] . Jennifer E L Templeton, Paul M Brotherton, Bastien Llamas, 2013

机译：DNA捕获和下一代测序可从高度降解的样品中恢复整个线粒体基因组，以供人类识别

DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification

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