Impaired Hepatitis C Virus (HCV)–Specific Interferon-γ Responses in Individuals With HIV Who Acquire HCV Infection: Correlation With CD4+ T-Cell Counts

Jacqueline K. Flynn13 Gregory J. Dore4 Gail Matthews4 Margaret Hellard2 Barbara Yeung4 William D. Rawlinson7 Peter A. White5 John M. Kaldor4 Andrew R. Lloyd6 Rosemary A. Ffrench13 and on behalf of the ATAHC Study Group

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Impaired Hepatitis C Virus (HCV)–Specific Interferon-γ Responses in Individuals With HIV Who Acquire HCV Infection: Correlation With CD4+ T-Cell Counts

机译：丙型肝炎病毒（HCV）受损-获得HCV感染的HIV个体中特定的γ-干扰素应答：与CD4 + T细胞计数的相关性

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Studies examining the effect of coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) on the HCV-specific immune response in acute HCV infection are limited. This study directly compared acute HCV-specific T-cell responses and cytokine profiles between 20 HIV/HCV-coinfected and 20 HCV-monoinfected subjects, enrolled in the Australian Trial in Acute Hepatitis C (ATAHC), using HCV peptide enzyme-linked immunospot (ELISPOT) and multiplex in vitro cytokine production assays. HIV/HCV coinfection had a detrimental effect on the HCV-specific cytokine production in acute HCV infection, particularly on HCV-specific interferon γ (IFN-γ) production (magnitude P = .004; breadth P = .046), which correlated with peripheral CD4+ T-cell counts (ρ = 0.605; P = .005) but not with detectable HIV viremia (ρ = 0.152; P = .534).

机译：审查与人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）共同感染对急性HCV感染中HCV特异性免疫反应的影响的研究非常有限。这项研究直接比较了使用HCV肽酶联免疫斑点法（AHC）在澳大利亚急性丙型肝炎（ATAHC）试验中入选的20名HIV / HCV合并感染者和20 HCV单一感染者之间的急性HCV特异性T细胞反应和细胞因子谱（ ELISPOT）和多种体外细胞因子生产测定。 HIV / HCV合并感染对急性HCV感染中HCV特异性细胞因子的产生有不利影响，尤其是对HCV特异性干扰素γ（IFN-γ）的产生（幅度P = .004；广度P = .046），与外周CD4 + T细胞计数（ρ= 0.605； P = .005），但未检测到HIV病毒血症（ρ= 0.152； P = .534）。

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《Journal of Infectious Diseases》 |2012年第10期|p.1568-1576|共9页
作者
Jacqueline K. Flynn13 Gregory J. Dore4 Gail Matthews4 Margaret Hellard2 Barbara Yeung4 William D. Rawlinson7 Peter A. White5 John M. Kaldor4 Andrew R. Lloyd6 Rosemary A. Ffrench13 and on behalf of the ATAHC Study Group;
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1Centre for Immunology, Burnet Institute 2Centre for Population Health, Burnet Institute 3Department of Immunology, Monash University, Melbourne 4Kirby Institute for Infection and Immunity in Society 5School of Biotechnology and Biomedical Sciences 6Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales 7Virology Division, Southern Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia;

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1. Impaired hepatitis C virus (HCV)-specific interferon-responses in individuals with HIV who acquire HCV infection: Correlation with CD4 + T-cell counts [J] . FlynnJ.K., DoreG.J., MatthewsG., The Journal of Infectious Diseases . 2012,第10期

机译：感染HCV的HIV感染者的丙型肝炎病毒（HCV）特异性干扰素应答受损：与CD4 + T细胞计数的相关性
2. Preservation of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses despite global loss of CD4+ T cells in HCV/HIV coinfection. [J] . Morishima C, Shuhart MC, Yoshihara CS, The Journal of Infectious Diseases . 2007,第4期

机译：尽管在HCV / HIV合并感染中CD4 + T细胞整体丢失，但仍保留了肝内丙型肝炎病毒（HCV）特异性CD4 + T细胞反应。
3. Preservation of Intrahepatic Hepatitis C Virus (HCV)-Specific CD4+ T Cell Responses despite Global Loss of CD4+ T Cells in HCV/HIV Coinfection [J] . Dr. Chihiro Morishima1 Margaret C. Shuhart2 Christina S. Yoshihara1a Denise M. Paschal1 Melissa A. Silva1 Lisa V. Thomassen3 Scott S. Emerson4 and David R. Gretch12 Journal of Infectious Diseases . 2007,第4期

机译：尽管在HCV / HIV合并感染中CD4 + T细胞整体丢失，但仍保留特定的肝内丙型肝炎病毒（HCV）CD4 + T细胞反应
4. Simultaneous extraction of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNA with the M1000 apparatus does not impair the measurement of the viral load of both viruses when tested by using the LCx PCR system [C] . T. Bourlet, S. Thamm, S. Pillet, European Congress of Virology . 2004

机译：通过使用LCX PCR系统测试，同时提取人免疫缺陷病毒类型1（HIV-1）和丙型肝炎病毒（HCV）RNA，不会损害两种病毒的病毒载量的测量
5. Hepatitis C virus (HCV) replication in vitro and the effect of HCV on human immunodeficiency virus (HIV-1) coreceptor usage and diversity in the coinfected patient. [D] . Franco, Kelly Flory. 2007

机译：丙型肝炎病毒（HCV）的体外复制以及HCV对合并感染患者中人免疫缺陷病毒（HIV-1）共受体使用和多样性的影响。
6. Impaired Hepatitis C Virus (HCV)–Specific Interferon-γ Responses in Individuals With HIV Who Acquire HCV Infection: Correlation With CD4+ T-Cell Counts [O] . Jacqueline K. Flynn, Gregory J. Dore, Gail Matthews, -1

机译：丙型肝炎病毒（HCV）受损-感染HCV的HIV感染者的特定干扰素-γ反应：与CD4 + T细胞计数的相关性
7. Kinetics of Intrahepatic Hepatitis C Virus (HCV)-Specific CD4+ T Cell Responses in HCV and Schistosoma mansoni Coinfection: Relation to Progression of Liver Fibrosis [O] . Kamal, Sanaa M., Graham, Camilla S., He, Qi, 2017

机译：丙型肝炎病毒和曼氏血吸虫合并感染中肝内丙型肝炎病毒（HCV）特异性CD4 + T细胞反应的动力学：与肝纤维化进展的关系

Impaired Hepatitis C Virus (HCV)–Specific Interferon-γ Responses in Individuals With HIV Who Acquire HCV Infection: Correlation With CD4+ T-Cell Counts

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