Preservation of Intrahepatic Hepatitis C Virus (HCV)-Specific CD4+ T Cell Responses despite Global Loss of CD4+ T Cells in HCV/HIV Coinfection

Dr. Chihiro Morishima1 Margaret C. Shuhart2 Christina S. Yoshihara1a Denise M. Paschal1 Melissa A. Silva1 Lisa V. Thomassen3 Scott S. Emerson4 and David R. Gretch12

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Preservation of Intrahepatic Hepatitis C Virus (HCV)-Specific CD4+ T Cell Responses despite Global Loss of CD4+ T Cells in HCV/HIV Coinfection

机译：尽管在HCV / HIV合并感染中CD4 + T细胞整体丢失，但仍保留特定的肝内丙型肝炎病毒（HCV）CD4 + T细胞反应

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Background. Human immunodeficiency virus (HIV) coinfection and low peripheral blood CD4+ T cell counts are associated with increased hepatitis C liver disease.

机译：背景。人类免疫缺陷病毒（HIV）合并感染和外周血CD4 + T细胞计数低与丙型肝炎肝病的增加有关。

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《Journal of Infectious Diseases》 |2007年第4期|577-586|共10页
作者
Dr. Chihiro Morishima1 Margaret C. Shuhart2 Christina S. Yoshihara1a Denise M. Paschal1 Melissa A. Silva1 Lisa V. Thomassen3 Scott S. Emerson4 and David R. Gretch12;
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Department of Laboratory Medicine University of Washington School of Medicine Seattle;

Department of Medicine University of Washington School of Medicine Seattle;

Department of Pathology University of Washington School of Medicine Seattle;

Department of Biostatistics University of Washington School of Medicine Seattle;

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1. Preservation of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses despite global loss of CD4+ T cells in HCV/HIV coinfection. [J] . Morishima C, Shuhart MC, Yoshihara CS, The Journal of Infectious Diseases . 2007,第4期

机译：尽管在HCV / HIV合并感染中CD4 + T细胞整体丢失，但仍保留了肝内丙型肝炎病毒（HCV）特异性CD4 + T细胞反应。
2. Kinetics of Intrahepatic Hepatitis C Virus (HCV)-Specific CD4+ T Cell Responses in HCV and Schistosoma mansoni Coinfection: Relation to Progression of Liver Fibrosis. [J] . Kamal SM, He Q, Tawil AA, The Journal of Infectious Diseases . 2004,第7期

机译：丙型肝炎病毒和曼氏血吸虫合并感染中肝内丙型肝炎病毒（HCV）特异性CD4 + T细胞反应的动力学：与肝纤维化进展的关系。
3. Impaired Hepatitis C Virus (HCV)–Specific Interferon-γ Responses in Individuals With HIV Who Acquire HCV Infection: Correlation With CD4+ T-Cell Counts [J] . Jacqueline K. Flynn13 Gregory J. Dore4 Gail Matthews4 Margaret Hellard2 Barbara Yeung4 William D. Rawlinson7 Peter A. White5 John M. Kaldor4 Andrew R. Lloyd6 Rosemary A. Ffrench13 and on behalf of the ATAHC Study Group Journal of Infectious Diseases . 2012,第10期

机译：丙型肝炎病毒（HCV）受损-获得HCV感染的HIV个体中特定的γ-干扰素应答：与CD4 + T细胞计数的相关性
4. The burden of the HIV viral load and of cell-to-cell spread in HIV/HCV coinfection [C] . Ana R. M. Carvalho, Carla M. A. Pinto Vienna International Conference on Mathematical Modelling . 2018

机译：艾滋病毒病毒载荷和艾滋病毒/ HCV辛纤维中细胞对细胞的负担
5. Hepatitis C virus (HCV) replication in vitro and the effect of HCV on human immunodeficiency virus (HIV-1) coreceptor usage and diversity in the coinfected patient. [D] . Franco, Kelly Flory. 2007

机译：丙型肝炎病毒（HCV）的体外复制以及HCV对合并感染患者中人免疫缺陷病毒（HIV-1）共受体使用和多样性的影响。
6. Impaired Hepatitis C Virus (HCV)–Specific Interferon-γ Responses in Individuals With HIV Who Acquire HCV Infection: Correlation With CD4+ T-Cell Counts [O] . Jacqueline K. Flynn, Gregory J. Dore, Gail Matthews, -1

机译：丙型肝炎病毒（HCV）受损-感染HCV的HIV感染者的特定干扰素-γ反应：与CD4 + T细胞计数的相关性
7. Preservation of Intrahepatic Hepatitis C Virus (HCV)–Specific CD4+T Cell Responses despite Global Loss of CD4+T Cells in HCV/HIV Coinfection [O] . Chihiro Morishima, Margaret C. Shuhart, Christina S. Yoshihara, 2007

机译：尽管HCV / HIV繁殖中的全球CD4 + T细胞的全局丧失，但在HCV / HIV繁殖中的全局损失，保存肝内丙型肝炎病毒（HCV）的特异性CD4 + T细胞反应

Preservation of Intrahepatic Hepatitis C Virus (HCV)-Specific CD4+ T Cell Responses despite Global Loss of CD4+ T Cells in HCV/HIV Coinfection

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