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首页> 外文期刊>Journal of Infectious Diseases >Antibody Induced by Immunization with the Jeryl Lynn Mumps Vaccine Strain Effectively Neutralizes a Heterologous Wild-Type Mumps Virus Associated with a Large Outbreak
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Antibody Induced by Immunization with the Jeryl Lynn Mumps Vaccine Strain Effectively Neutralizes a Heterologous Wild-Type Mumps Virus Associated with a Large Outbreak

机译：由杰里琳·流行性腮腺炎疫苗株免疫接种诱导的抗体可有效中和与大规模暴发相关的异源野生型流行性腮腺炎病毒

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Recent mumps outbreaks in older vaccinated populations were caused primarily by genotype G viruses, which are phylogenetically distinct from the genotype A vaccine strains used in the countries affected by the outbreaks. This finding suggests that genotype A vaccine strains could have reduced efficacy against heterologous mumps viruses. The remote history of vaccination also suggests that waning immunity could have contributed to susceptibility. To examine these issues, we obtained consecutive serum samples from children at different intervals after vaccination and assayed the ability of these samples to neutralize the genotype A Jeryl Lynn mumps virus vaccine strain and a genotype G wild-type virus obtained during the mumps outbreak that occurred in the United States in 2006. Although the geometric mean neutralizing antibody titers against the genotype G virus were approximately one-half the titers measured against the vaccine strain, and although titers to both viruses decreased with time after vaccination, antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralized the outbreak-associated virus at all time points tested.
机译：在较老的接种人群中最近流行性腮腺炎的暴发主要是由基因型G病毒引起的，G基因型病毒在系统发育上与受疫情影响的国家所使用的基因型A疫苗株不同。这一发现表明，基因型A疫苗株对异源性腮腺炎病毒的功效可能降低。远距离的疫苗接种历史也表明，免疫力下降可能导致了易感性。为了检查这些问题，我们在接种疫苗后的不同间隔从儿童那里获取了连续的血清样本，并分析了这些样本中和A型杰里琳·腮腺炎腮腺炎病毒疫苗株和腮腺炎暴发期间获得的G型野生型病毒的能力。在2006年的美国。虽然针对基因G型病毒的几何平均中和抗体效价约为针对疫苗株的效价的一半，并且尽管对两种病毒的效价随接种时间的推移而降低，但用G病毒免疫诱导的抗体Jery​​l Lynn腮腺炎疫苗株在所有测试时间点均有效中和了与爆发相关的病毒。

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